Adaptive Goal-directed Adherence Tracking and Enhancement (AGATE)

在该项目的第一阶段(SBIR PHS 2008-1，“测量和提高药物依从性的方法学的发展”，主题33)下，设计了依从性跟踪和增强系统(玛瑙)。玛瑙原型使用现代蜂窝电话的文本消息和互联网功能来解决临床护理和临床试验环境中的药物依从性问题。 在第二阶段，原型将被开发成可商业化的产品，可以与任何药物一起使用。将进行形成性评估，包括与协调参与者参与药物治疗试验或管理患者用药方案的研究护士进行可用性测试。玛瑙将与心理研究网络和新墨西哥大学的经验丰富的药物研究人员合作，在纳曲酮治疗问题饮酒的药物疗法试验的背景下进行评估，以确定它是否改善了药物依从性。纳曲酮是一种非常有希望的酒精依赖疗法。

Under Phase I of the project (SBIR PHS 2008-1, "Development of Methodology for Measuring and Enhancing Compliance for Medications, Topic 33), an adherence tracking and enhancement system (AGATE) was designed. The AGATE prototype uses the text messaging and internet capabilities of modern cellular phones to address the problem of medication adherence in clinical care and clinical trial contexts. In Phase II the prototype will be developed into a commercializable product which can be used in conjunction with any medication. Formative evaluation to include usability testing with research nurses who coordinate participant involvement in pharmacotherapy trials or manage patients' medication regimens will be conducted. In collaboration with experienced drug researchers at the Mind Research Network and the University of New Mexico, AGATE will be evaluated to determine whether it improves medication adherence in the context of a pharmacotherapy trial of naltrexone, a highly promising treatment for alcohol dependence, to treat problem drinking.