Predicting dementia with practice effects

通过实践效果预测痴呆症

• 批准号: 7874540
• 负责人: KEVIN M DUFF
• 金额: $ 14.42万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7874540
• 关键词: Address; Affect; Age; Aging; Amyloid beta-Protein; Apolipoprotein E; Build-it; Cerebrospinal Fluid; Clinical; Clinical Trials; Cognition; Cognition Disorders; Cognitive; Cognitive aging; Comorbidity; Data; Decision Making; Dementia; Diagnosis; Disease; Disease Progression; Doctor of Philosophy; Early identification; Education; Effect Modifiers (Epidemiology); Elderly; Ethics; Family Planning; Foundations; Funding; Gender; Goals; Hippocampus (Brain); Impaired cognition; Iowa; Knowledge; Legal; Magnetic Resonance Imaging; Medical; Memory Disorders; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Mission; National Institute on Aging; Neurodegenerative Disorders; Outcome; Outcome Measure; Patients; Pattern; Perfusion; Positioning Attribute; Positron-Emission Tomography; Procedures; Public Health; Research; Research Activity; Research Personnel; Research Project Grants; Research Proposals; Resources; Risk; Sampling; Series; Techniques; Training; Training Support; Universities; Writing; age related; clinical care; clinical practice; cognitive change; cost effective; experience; heuristics; improved; indexing; interest; mild neurocognitive impairment; multidisciplinary; normal aging; novel; prognostic indicator; programs; progression marker; skills; success; tau-1

DESCRIPTION (provided by applicant): This revised Mentored Patient-Oriented Research Career Development Award ,(K23) application is a request to support the training and research activities necessary for Kevin Duff, Ph.D. to further develop a novel cognitive index (i.e., practice effects), which could assist in the prediction of outcomes in Mild Cognitive Impairment (MCI). Although the concept of MCI has' advanced our understanding of the transition between normal aging and dementia, it remains an imperfect heuristic for identifying which patients will progress to dementia, and which will not.The current research proposal will examine if there is an inverse relationship between practice effects and cognitive outcome, so that an absence of practice effects increases the risk for conversion to dementia in amnestic MCI across 2 years; and, conversely, robust practice effects are associated with a decreased risk for dementia. Specifically, this research plan will address the following research aims: 1) determine if practice effects predict conversion to dementia in MCI, and 2) examine a variety of moderators of practice effects, and see how they affect conversion rates. The training plan detailed in this application offers a multidisciplinary program capitalizing on the diverse resources available at the University of Iowa and on the expertise of national researchers in memory disorders. As a neuropsychologist, Dr. Duff has set the following training goals: 1) develop skills necessary to further develop practice effects as a predictor of cognitive decline, 2) gain additional expertise in tracking cognitive decline in MCI and diagnosing dementia, 3) gain knowledge in identifying moderators of MCI to dementia conversion, and 4) expand knowledge of statistical techniques necessary for answering these questions. Additionally, training will be provided in conducting ethical research and grant writing. The training and proposed project will lay the foundation for Dr. Duffs long-term scientific goal of creating an independent and externally-funded program of research on examining markers of disease progression in normal aging, MCI, and dementia. Identifying early markers of progression from normal aging to MCI to dementia clearly fits with the mission of the National Institute on Aging, in that, it provides greater knowledge about aging and aging- related diseases. Additionally, identification of early cognitive disorders can have profound public health significance with inaccurate or delayed identification of these disorders leading to missed opportunities for treatment and medical, legal, and family planning. Finally, the availability of a brief, non-invasive, and cost effective marker of disease progression would allow for more efficient and better powered clinical trials.

描述（由申请人提供）：此修订后的指导以患者为导向的研究职业发展奖，（K23）应用程序是一个请求，以支持凯文达夫博士所需的培训和研究活动。为了进一步开发新的认知指数（即，实践效果），这可能有助于预测轻度认知障碍（MCI）的结果。虽然MCI的概念已经“推进了我们对正常衰老和痴呆之间过渡的理解，但它仍然是一个不完善的启发式方法，用于识别哪些患者会发展为痴呆，哪些不会。目前的研究提案将检查练习效果和认知结果之间是否存在反比关系，因此，缺乏练习效应会增加遗忘型MCI在2年内转化为痴呆的风险;相反，强大的练习效应与痴呆风险降低相关。具体而言，本研究计划将解决以下研究目标：1）确定实践效果是否预测MCI中痴呆症的转化，以及2）检查实践效果的各种调节因素，并查看它们如何影响转化率。本申请中详细介绍的培训计划提供了一个多学科计划，利用了爱荷华州大学的各种资源和国家研究人员在记忆障碍方面的专业知识。作为一名神经心理学家，Duff博士设定了以下培训目标：1）发展必要的技能，以进一步发展实践效果作为认知下降的预测因素，2）获得跟踪MCI认知下降和诊断痴呆症的额外专业知识，3）获得识别MCI向痴呆症转换的调节剂的知识，以及4）扩展回答这些问题所需的统计技术知识。此外，还将提供进行伦理研究和撰写赠款方面的培训。培训和拟议的项目将为Duffs博士的长期科学目标奠定基础，即建立一个独立的外部资助的研究计划，研究正常衰老，MCI和痴呆症中疾病进展的标志物。确定从正常衰老到MCI再到痴呆的早期进展标志物显然符合国家老龄问题研究所的使命，因为它提供了更多关于衰老和衰老相关疾病的知识。此外，早期认知障碍的识别可能具有深远的公共卫生意义，这些障碍的不准确或延迟识别导致错过治疗和医疗、法律的和计划生育的机会。最后，一个简短的，非侵入性的，具有成本效益的疾病进展标志物的可用性将允许更有效和更好的动力临床试验。