PROJECT 14

项目14

• 批准号: 8337779
• 负责人: Irene Ann Chen
• 金额: $ 23.98万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8337779
• 关键词: Accounting; Acquired Immunodeficiency Syndrome; Antibiotic Resistance; Bacterial Infections; Biodiversity; Biological Phenomena; Biology; Cells; Communities; Cystic Fibrosis; Disease; Ecosystem; Engineering; Environment; Evolution; Gene Expression; Gene Expression Alteration; Generations; Genetic Variation; Goals; Individual; Individual Differences; Malignant Neoplasms; Mutation; Mycoses; Noise; Organism; Pathway interactions; Pattern; Pharmaceutical Preparations; Phenotype; Play; Predisposition; Process; Proteins; Research; Role; Scientist; Social Behavior; Structure; Time; circadian pacemaker; pathogen; protein folding; research study; response; theories

This proposal focuses on the generation, control, and exploitation of diversity in biology. Genetic diversity drives the evolution of organisms, hinders cures of cystic fibrosis, AIDS and cancer, plays a crucial role in bacterial and fungal infections, and accounts for individual differences in susceptibility to disease agents and the responses to drugs. Non-.genetic diversity allows different cells to respond differently to the same environment, differences that can increase the infectivity of pathogens and their resistance to antibiotics. This team will use experiment and theory to study the origin and consequences of biological diversity over scales of size and time that range from the folding of individual proteins to the formation of new species. The core of the proposal is the group of Bauer fellows, young interdisciplinary scientists who come from a variety of backgrounds and interact to form a single collaborative community that nucleates interactions amongst a wide range of research groups.

该提案的重点是生物多样性的产生、控制和利用。遗传多样性驱动着生物体的进化，阻碍了囊性纤维化、艾滋病和癌症的治愈，在细菌和真菌感染中起着至关重要的作用，并解释了个体对疾病病原体的易感性和对药物的反应的差异。非遗传多样性允许不同的细胞对相同的环境做出不同的反应，这些差异可以增加病原体的感染性及其对抗生素的抗性。 该团队将使用实验和理论来研究生物多样性的起源和后果，其范围从单个蛋白质的折叠到新物种的形成。该提案的核心是鲍尔研究员小组，他们是来自各种背景的年轻跨学科科学家，他们相互作用，形成一个单一的协作社区，在广泛的研究小组之间进行互动。