TRIAD Legacy Study allowing additional analyses of TRIAD dataset to be performed

TRIAD Legacy Study 允许对 TRIAD 数据集进行额外分析

• 批准号: 8111260
• 负责人: DAVID Grayson MARRERO
• 金额: $ 11.5万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-12 至 2013-07-11
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8111260
• 关键词: TRIAD; Legacy; Study; allowing; additional

DESCRIPTION OF THE PROJECT: This application presents 6 analyses proposals that utilize data collected as part of the TRIAD study between 2000 and 2006. TRIAD is a multicenter prospective cohort study. It includes data collected at baseline (round 1) from approximately 12,000 individuals during 2000-2001, follow-up data (round 2) collected 18-months later from approximately 9,000 of the original participants during 2002-2003, and a second follow-up (round 3) collected data from approximately 6,000 individuals of the original cohort of participants during 2005. Data were also collected from health plans, provider groups, and individual providers. In addition, a fourth survey, the Cardiovascular Risk Survey, targeted those at high risk for CVD events and a comparison group of well-controlled patients. These focused surveys are cross-sectional in design and focus on reasons for poor intermediate outcomes (i.e., poor levels of control of A1C, blood pressure, and LDL-C). Data were collected from 1,137 individuals during 2005-2006. Patient data were collected via computer assisted telephone interviews (CATI) and mailed questionnaires to optimize response rates. The 6 analyses proposed here are part of a legacy study that seeks to extend the scientific questions that can be asked from the data sets. At the Indiana University (IU) TRIAD site, we have elected to focus primarily on the Cardiovascular Risk Survey to address the following questions and illuminate the following issues: 1) What are the correlates of CVD risk factor control in adults with diabetes; 2) What is the role that patient-perceived barriers to medication use play in CVD outcomes; 3) What is the correlation between patients risk perception and control of cardiovascular risk factors; and 4) Understanding physicians' decisions to initiate or not initiate insulin in type 2 patients who are oral hyperglycemic failures. In addition, the IU TRIAD site will also evaluate two pilot interventions that were conducted with the IU TRIAD collaborating health plans; 1) Evaluating the impact of a pilot intervention to improve medication adherence in diabetic adults with self-reported barriers to taking medications as prescribed by their providers, 2) Process and outcomes of efforts to implement clinic-community linkages to prevent Type 2 diabetes in 3 systems of health care.

项目描述：该应用程序提出了6项分析建议，这些建议利用了2000年至2006年期间作为TRIAD研究的一部分收集的数据。TRIAD是一项多中心前瞻性队列研究。它包括在2000-2001年期间从大约12，000人中收集的基线数据（第1轮），2002-2003年期间从大约9，000名原始参与者中收集的18个月后的随访数据（第2轮），以及第二轮随访（第3轮）收集的大约6，000人的数据。在2005年，最初的一批参与者中有2000人。数据还收集了健康计划，提供者团体和个人提供者。此外，第四项调查，心血管风险调查，针对那些高风险的心血管事件和对照组控制良好的患者。这些有重点的调查在设计上是横断面的，重点是中间结果不佳的原因（即，A1 C、血压和LDL-C控制水平差）。2005-2006年期间，从1 137名个人收集了数据。通过计算机辅助电话访谈（CATI）和邮寄问卷收集患者数据，以优化应答率。这里提出的6项分析是一项传统研究的一部分，该研究旨在扩展可以从数据集中提出的科学问题。在印第安纳州大学（IU）TRIAD研究中心，我们选择主要关注心血管风险调查，以解决以下问题并阐明以下问题：1）成年糖尿病患者心血管风险因素控制的相关性是什么; 2）患者感知的药物使用障碍在心血管疾病结局中的作用是什么; 3）患者的风险感知与心血管风险因素的控制之间的相关性是什么;以及4）理解医生对口服高血糖失败的2型患者开始或不开始胰岛素治疗的决定。此外，IU TRIAD网站还将评估与IU TRIAD合作健康计划进行的两项试点干预措施; 1）评估试点干预措施对改善自我报告有障碍的糖尿病成人的药物依从性的影响，这些障碍是按照其提供者的处方服用药物，2）在3个卫生保健系统中实施诊所-社区联系以预防2型糖尿病的努力的过程和结果。