Mechanisms of molecular machines that regulate the neuronal cytoskeleton

调节神经元细胞骨架的分子机器机制

• 批准号: 8158250
• 负责人: Antonina Roll-Mecak
• 金额: $ 124.08万
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8158250
• 关键词: Cues; Cytoskeleton; Molecular Machines; Neurons

Our efforts in the last year have concentrated on the microtubule severing enzyme spastin. Spastin is mutated in 40% of hereditary spastic paraplegias, a group of neurodegenerative disorders characterized by axonopathy. We have previously determined the X-ray structure of spastin and proposed a novel mechanism for microtubule severing (Roll-Mecak and Vale, 2008). We have made progress in the last year on Aim 1a of our research program that concentrates on understanding the biophysical mechanism of microtubule severing enzymes, specifically the interaction between spastin and the microtubule.

我们在过去一年的努力集中在微管切断酶痉挛。 痉挛蛋白在40%的遗传性痉挛性截瘫中发生突变，这是一组以轴突病变为特征的神经退行性疾病。我们之前已经确定了spastin的X射线结构，并提出了一种新的微管切断机制（Roll-Mecak和Vale，2008）。 在过去的一年里，我们在我们的研究计划的目标1a上取得了进展，该计划专注于了解微管切断酶的生物物理机制，特别是痉挛素和微管之间的相互作用。