Bioinformatics Inquiry through Sequencing (BIOSEQ)

描述（由申请人提供）：通过测序进行生物信息学调查（BIOSEQ）项目的总体目标是为广大受众提供机会，通过基于调查的研究了解生物信息学领域。三项主要活动将支持这一目标： 1. 通过在塔夫茨大学的梅德福校区建立一个用于教育用途的测序中心，增加学生和教育工作者对基于探究的生物信息学研究的了解和参与。 该测序中心将通过大学水平的研究课程提供给大学生和高中生，也将提供给希望通过应用程序将测序融入课堂项目，科学博览会项目，大学水平论文和研究生水平研究的教育工作者和学生。 2. 通过入门级、为期一学期的研究课程向大学生和高中生介绍生物信息学，旨在在学生设计的项目背景下教授学生实验室技能、计算机技能和研究技能。 高中生课程将在夏季课程期间进行，学生将能够获得大学学分。奖学金将提供给代表性不足的少数民族和社会经济地位低的人参加课程。 3. 通过开发模块活动和课程单元来描述生物信息学概念，包括生物信息学对科学和医学研究的影响，增加教师的生物信息学知识，并将生物信息学概念纳入其课程。 其中一些活动和单元将被整合到现有的高中生物学和计算机科学课程中，并将包括生物信息学和基因组学如何通过全基因组关联研究（GWAs）和直接面向消费者（DTC）基因检测等创新影响个人和公共健康的理解。 这个为期五年的项目将涉及教师，工作人员，研究生和本科生从塔夫茨大学的化学和计算机科学系，教师和学生从掩体山社区学院，教师和高中学生从四个不同的，城市的合作伙伴学区。

DESCRIPTION (provided by applicant): The overall goal for the Bioinformatics Inquiry through Sequencing (BIOSEQ) project is to provide opportunities for a broad audience of people to learn about the field of bioinformatics through inquiry based research. Three main activities will support this goal: 1. Increase knowledge of and participation in inquiry-based bioinformatics research among students and educators by establishing a sequencing center at Tufts University's Medford Campus for educational use. This sequencing center will be available to college students and high school students through college level research courses and will also be available to educators and students who wish to integrate sequencing into classroom projects, science fair projects, college level theses and graduate level research through an application process. 2. Introduce bioinformatics to college students and high school students through entry level, semester-long research-based courses designed to teach students laboratory skills, computer skills and research skills in the context of student designed projects. The high school student course will happen during the summer session, students will be able to receive college credit. Scholarships will be available for underrepresented minorities and those of low socioeconomic status to participate in the course. 3. Increase teacher knowledge of bioinformatics and inclusion of bioinformatics concepts in their courses by developing modular activities and curricular units to describe bioinformatics concepts, including the impact of bioinformatics on scientific and medical research. Some of these activities and units will be integrated into existing high school biology and computer science courses, and will include understanding of how bioinformatics and genomics have influenced individual and public health through innovations such as Genome Wide Association studies (GWAs) and Direct to Consumer (DTC) genetic testing. This five year project will involve faculty, staff, graduate students, and undergraduate students from Tufts' Chemistry and Computer science departments, faculty and students from Bunker Hill Community College, and teachers and high school students from four diverse, urban partner school districts.