Predoctoral and Postdoctoral Training in Cancer Cell Biology

癌细胞生物学博士前和博士后培训

• 批准号: 8078809
• 负责人: MARILYN Gist FARQUHAR
• 金额: $ 22.95万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-25 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8078809
• 关键词: Cellular biology; cancer cell; post-doctoral training; pre-doctoral

DESCRIPTION (provided by applicant): This proposal requests support for a predoctoral and postdoctoral training program in basic Cancer Cell Biology. The program goal is to prepare trainees for careers in basic or clinically-related Cancer Research in academic institutions or industry. The training faculty are drawn from the Departments of Cellular and Molecular Medicine (DCCM), Medicine, Pediatrics, Pharmacology and Surgery, the Moore's UCSD Cancer Center, the Ludwig Institute for Cancer Research (LICR), and the Howard Hughes Medical Institute (HHMI). The faculty includes individuals active in both basic and preclinical translational cancer research. This program is the only predoctoral and postdoctoral cancer biology training program based in the School of Medicine and is integrated into the Biomedical Sciences (BMS) Graduate Program which is a broadly based program in cell and molecular biology, genetics/genomics, immunology, pharmacology and physiology. The training faculty strongly believes that to cure the derangements of cell processes that occur in cancer cells requires detailed understanding of the molecular, cellular and genetic aspects of normal and abnormal cell behavior and their application to cancer research. Faculty: Each of the 29 faculty is internationally recognized in his/her field, has an outstanding training record, and has research interests that are fundamental to understanding cancer cell biology-- including cell cycle control, oncogenes and anti-cancer genes, regulatory kinases, signaling, growth control, G proteins and growth factors, control of cell movement, glycobiology of cancer cells, cellular and molecular genomics, and the development of experimental anticancer therapeutics. Trainees: Predoctoral trainees will be selected from students in the BMS graduate program based on their interest in undertaking research in basic cancer cell biology and on the strength of their academic and research performance. Postdoctoral trainees will be selected from those applying for positions in the laboratories of the training faculty based on their academic achievements and interest in a career in cancer research. We are requesting 6 predoctoral and 2 postdoctoral positions in year 16 increasing gradually to reach 6 postdoctoral trainees in year 20. Trainees are required to complete the specialized Cancer Trainee Program requirements, including a monthly research workshop and annual retreat and courses in Cancer Research, the Responsible Conduct of Research, tutorials, small group conferences on the cellular/molecular biology of cancer, attendance at the joint DCMM/Ludwig seminar series as well as a seminar series on the clinical aspects of cancer and the response of tumor cells to various treatments sponsored by the Moores UCSD Cancer Center. PUBLIC HEALTH RELEVANCE: To cure the derangements of cell processes that occur in cancer cells requires detailed understanding of the molecular, cellular and genetic aspects of normal and abnormal cell behavior and their application to cancer research. The goal of this Cancer Cell Biology program is to prepare predoctoral and postdoctoral trainees for careers in basic or clinically-related Cancer Research in academic institutions or industrial institutions. This state-of-the-art training experience will equip trainees to become leaders in developing research programs and strategies that will improve cancer diagnosis and treatment for cancer patients.

描述（由申请人提供）：本提案要求支持基础癌细胞生物学的博士前和博士后培训计划。该计划的目标是为学员在学术机构或行业的基础或临床相关的癌症研究职业做好准备。培训教师来自细胞和分子医学（DCCM），医学，儿科，药理学和外科，摩尔的UCSD癌症中心，路德维希癌症研究所（LICR）和霍华德休斯医学研究所（HHMI）的部门。教师包括活跃在基础和临床前转化癌症研究的个人。该项目是医学院唯一的博士前和博士后癌症生物学培训项目，并被整合到生物医学科学（BMS）研究生项目中，该项目是一个基础广泛的细胞和分子生物学、遗传学/基因组学、免疫学、药理学和生理学项目。培训教师坚信，要治愈癌细胞中发生的细胞过程紊乱，需要详细了解正常和异常细胞行为的分子、细胞和遗传方面及其在癌症研究中的应用。 学院：29名教师中的每一个都在他/她的领域得到国际认可，具有出色的培训记录，并具有对理解癌细胞生物学至关重要的研究兴趣-包括细胞周期控制，致癌基因和抗癌基因，调节激酶，信号传导，生长控制，G蛋白和生长因子，细胞运动控制，癌细胞糖生物学，细胞和分子基因组学，以及实验性抗癌疗法的发展。 受训人员：博士前实习生将根据他们对基础癌细胞生物学研究的兴趣以及他们的学术和研究表现从BMS研究生课程的学生中选出。博士后研究生将根据他们的学术成就和对癌症研究职业的兴趣，从申请培训学院实验室职位的人员中挑选。我们要求在16年6个博士前和2个博士后职位，逐渐增加到20年达到6个博士后培训生。学员必须完成专门的癌症培训生计划的要求，包括每月的研究讲习班和年度务虚会和癌症研究，负责任的研究行为，教程，癌症细胞/分子生物学小组会议，出席联合DCMM/路德维希研讨会系列以及关于癌症的临床方面和肿瘤细胞对各种治疗的反应的研讨会系列，由摩尔UCSD癌症中心 公共卫生关系：为了治愈癌细胞中发生的细胞过程的紊乱，需要详细了解正常和异常细胞行为的分子，细胞和遗传方面及其在癌症研究中的应用。该癌症细胞生物学计划的目标是为学术机构或工业机构的基础或临床相关癌症研究职业做好博士前和博士后培训。这种最先进的培训经验将使学员成为制定研究计划和策略的领导者，这些计划和策略将改善癌症患者的癌症诊断和治疗。