Molecular Mechanisms of Impaired Angiogenesis in Aging Gastric Mucosa

老化胃粘膜血管生成受损的分子机制

• 批准号: 8195628
• 负责人: ANDRZEJ S TARNAWSKI
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8195628
• 关键词: 5' -AMP-activated protein kinase; Acetylation; Acute; Age Reporting; Age-Years; Aging; Albumins; American; Angiogenesis Inhibition; Angiogenesis Inhibitors; Angiogenic Factor; Angiostatins; Antibodies; Apoptosis; Area; Arthritis; Asses; Binding; Biochemical; Blood Vessels; Blood capillaries; CREB1 gene; Cell Nucleus; Cell physiology; Cells; Characteristics; Chronic; Cicatrix; Clinical; Complementary DNA; Connective Tissue; DNA Binding; Dermal; Down-Regulation; Duodenal Ulcer; Economics; Endostatins; Endothelial Cells; Enzymes; Epithelial; Equilibrium; Ethanol; Exhibits; Extravasation; Fluorescein; Funding; Gastric mucosa; Gastric ulcer; Gastritis; Gelatinase B; Gene Activation; Gene Expression; Genes; Genetic Transcription; Goals; Granulation Tissue; HIF1A gene; Healed; Health; Heat shock proteins; Heat-Shock Proteins 90; Human; Hypoxia; Hypoxia Inducible Factor; Image; Imagery; Impaired wound healing; Impairment; Importins; In Vitro; Incidence; Indomethacin; Infarction; Injury; Investigation; Literature; Mediating; Molecular; Morbidity - disease rate; Myocardium; Natural regeneration; Non-Steroidal Anti-Inflammatory Agents; Nuclear; Nutrient; Organ; Oxygen; Pain; Patients; Peptic Ulcer; Pericytes; Permeability; Phosphorylation; Physiological; Plasmids; Population; Predisposition; Prevalence; Properdin; Proteins; Publications; Rattus; Relative (related person); Research; Research Design; Resolution; Role; STAT3 gene; Serum; Site; Small Interfering RNA; Stimulus; Stomach; Structure; Techniques; Technology; Testing; Therapeutic Intervention; Time; Tissues; Transcriptional Activation; Ulcer; Up-Regulation; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors; Vascular Permeabilities; Veterans; Work; Wound Healing; age related; alcohol response; alpha Karyopherins; angiogenesis; annexin A5; autocrine; base; capillary; density; gene therapy; healing; high risk; hypoxia inducible factor 1; improved; in vivo; indexing; injured; instrument; mortality; mouse model; mutant; neutralizing antibody; novel; novel therapeutic intervention; novel therapeutics; overexpression; patient population; promoter; protein expression; protein kinase P; receptor; response; response to injury; stem; transcription factor; treatment strategy