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Mu-Opioid Effects on the Central Mechanisms that Control Breathing

Mu-Opioid Effects on the Central Mechanisms that Control Breathing
Mu-阿片类药物对控制呼吸的中枢机制的影响
批准号：
8195947
负责人：
Edward J Zuperku
金额：
$0.0万
依托单位：
CLEMENT J. ZABLOCKI VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-04-01 至 2014-03-31
来源：
https://reporter.nih.gov/project-details/8195947
关键词：
AMPA ReceptorsAbsence of pain sensationAcuteAcute PainAddressAdrenergic AgentsAdrenergic ReceptorAdverse effectsAffectAgonistAminesAnalgesicsApneaAreaAxonBathingBilateralBiogenic Amine ReceptorsBrainBrain NeoplasmsBrain StemBreathingCanis familiarisCardiovascular systemCell NucleusCellsCervical spinal cord structureChronicClinicalComplexComputersConsensusDegenerative DisorderDepressed moodDiseaseDopamineDopamine AgonistsDorsalEffectivenessElectrodesEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Environmental air flowExhibitsFelis catusFentanylFinancial compensationFrequenciesGenerationsGlutamatesGlycine ReceptorsHeadHypertensionIn VitroInfusion proceduresInjuryIntravenous infusion proceduresKnowledgeLaboratoriesLifeLungMalignant NeoplasmsMeasuresMediatingMental DepressionMetabolic syndromeMethodsMicroinjectionsModelingMonitorMorphineN-Methyl-D-Aspartate ReceptorsNaloxoneNarcotic AntagonistsNeuromodulatorNeuronsNeuropharmacologyNeurotransmittersNorepinephrineNucleus solitariusObstructive Sleep ApneaOpiatesOpioidOpioid AnalgesicsOpioid ReceptorPainPain managementPathologicPatternPerioperativePharmaceutical PreparationsPharmacologyPhasePlasmaPontine structurePopulationPostoperative PainPropertyPulmonary Stretch ReceptorsPumpRattusReceptor InhibitionRespirationRespiratory physiologyRoleSeriesSerotoninSerotonin AgonistsSimulateSiteStructure of phrenic nerveSurfaceSynapsesSystemTechniquesTherapeuticTidal VolumeTimeTraumaVentilatory DepressionVeteransWorkadrenergicairway obstructionanalogbasechronic painclinical applicationclinically relevantdensitydesigndosageimmunoreactivityin vivoinsightlateral columnmu opioid receptorsnetwork modelsneurophysiologyneurotransmissionnoradrenergicpatient populationpostsynapticpresynapticpreventreceptorremifentanilresearch studyrespiratoryresponseserotonin receptortherapeutic target

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