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Glutamate dyshomeostasis: The role of glutamate transport dysfunction in Alzheim

Glutamate dyshomeostasis: The role of glutamate transport dysfunction in Alzheim
谷氨酸稳态失调：谷氨酸转运功能障碍在阿尔茨海默病中的作用
批准号：
7907841
负责人：
David G Cook
金额：
$0.0万
依托单位：
VA PUGET SOUND HEALTHCARE SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-10-01 至 2013-09-30
来源：
https://reporter.nih.gov/project-details/7907841
关键词：
APP-PS1AccountingAddressAffectAgingAllelesAlzheimer&aposs DiseaseAmyloid beta-Protein PrecursorAnimal ModelAstrocytesBiologicalBrainBrain regionClinicalClinical TrialsCognitionCognitiveDataDiseaseDisease ProgressionFamilyFunctional disorderGlutamate TransporterGlutamatesHippocampus (Brain)HumanLightMemantineMemoryModelingMusNeurobehavioral ManifestationsNeuronal PlasticityNeurotransmittersPathogenesisPathologyPatientsPharmaceutical PreparationsPlayPopulationPost-Translational Protein ProcessingPresynaptic TerminalsProcessPropertyRelative (related person)RiskRisk FactorsRoleStagingSynapsesSystemTestingTherapeuticVeteransadductbrain cellclinically relevantexcitotoxicityfamilial Alzheimer diseasehuman tissuemouse modelmutantneurotransmissionnew therapeutic targetnovelpresenilin-1preventpublic health relevancetooltreatment strategy

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