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Role of EphA2 RTK in tumor resistance to EGFR/HER2 inhibitors

Role of EphA2 RTK in tumor resistance to EGFR/HER2 inhibitors
EphA2 RTK 在肿瘤对 EGFR/HER2 抑制剂耐药中的作用
批准号：
7912971
负责人：
Jin Chen
金额：
$0.0万
依托单位：
VETERANS HEALTH ADMINISTRATION
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-10-01 至 2014-03-31
来源：
https://reporter.nih.gov/project-details/7912971
关键词：
AgeAntibodiesAntineoplastic AgentsBiochemicalBreastBreast AdenocarcinomaBreast Cancer CellBreast MelanomaCancer PatientCancer cell lineCause of DeathCell LineCellsClinicClinicalClinical ResearchCombined Modality TherapyComplexDataDevelopmentDiseaseDisease-Free SurvivalDrug Delivery SystemsDrug resistanceEGFR inhibitionERBB2 geneEph Family ReceptorsEphA ReceptorsEphA2 ReceptorEpidermal Growth Factor ReceptorErbB Receptor Family ProteinExhibitsFDA approvedFluorescence Resonance Energy TransferGefitinibGlioblastomaHead and Neck Squamous Cell CarcinomaHomologous GeneHumanIn VitroLaboratoriesLarge Intestine CarcinomaLinkMAP Kinase GeneMalignant NeoplasmsMediatingMolecularMonitorMonoclonal AntibodiesMouse Mammary Tumor VirusNon-Small-Cell Lung CarcinomaOncogene ErbB2Ovarian CarcinomaPathway interactionsPatientsPhosphorylationPlayPopulationPrincipal InvestigatorProstate carcinomaProtein Tyrosine KinaseRattusReporterReportingResearchResistanceRoche brand of trastuzumabRoleSeriesSignal PathwaySignal TransductionSmall Interfering RNATestingTherapeuticTransgenic ModelTrastuzumabTyrosine Kinase InhibitorUp-RegulationVascular Endothelial Growth FactorsVeteransangiogenesisbasebladder Carcinomacancer cellcancer therapycancer typedesignhuman monoclonal antibodiesin vivoinhibitor/antagonistkinase inhibitorknock-downmalignant breast neoplasmmammary epitheliummemberneoplastic cellnew therapeutic targetnoveloverexpressionpreclinical studyprogramspublic health relevancereceptor expressionresearch studyresistance mechanismrho GTP-Binding Proteinssmall moleculesuccesstumortumor initiationtumor progressiontumorigenesis

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Vascular regulation of fatty acid transport in metastatic tumor outgrowth
BLRD Merit Review Research Career Scientist (RCS) Award (IK6)
  • 批准号：
    10337024
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    2020
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BLRD Merit Review Research Career Scientist (RCS) Award (IK6)
  • 批准号：
    10091653
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    2020
  • 负责人：
    Jin Chen
  • 依托单位：
    VETERANS HEALTH ADMINISTRATION
BLRD Merit Review Research Career Scientist (RCS) Award (IK6)
  • 批准号：
    10514613
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
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  • 负责人：
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  • 依托单位：
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