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Genotyping and Phenotyping the Hepatitis C Drug Target NS5A

Genotyping and Phenotyping the Hepatitis C Drug Target NS5A
丙型肝炎药物靶点 NS5A 的基因分型和表型分析
批准号：
8195980
负责人：
ROBERT T STRIKER
金额：
$0.0万
依托单位：
WM S. MIDDLETON MEMORIAL VETERANS HOSP
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-04-01 至 2012-06-30
来源：
https://reporter.nih.gov/project-details/8195980
关键词：
Adverse effectsAffinityAntiviral AgentsAntiviral TherapyBiochemicalBreedingCaringCatalogingCatalogsCellsChronic Hepatitis CClinical DataClinical TrialsCommunicable DiseasesConsensus SequenceContractsCost of IllnessCyclophilinsCyclosporineDataDatabasesDevelopmentDiseaseDrug CombinationsDrug Delivery SystemsDrug toxicityEpidemicEvolutionFDA approvedFamilyGeneticGenetic DatabasesGenetic RecombinationGenetic VariationGenotypeHIVHealthHealthcare SystemsHepatitis CHepatitis C virusImmuneImmunoprecipitationImmunosuppressionImmunosuppressive AgentsIn VitroIndustryInterferonsInvestmentsLeadLightLinkLiverLiver diseasesMalignant neoplasm of liverMono-SMorbidity - disease rateNon-Hodgkin&aposs LymphomaNonstructural ProteinOrgan TransplantationOutcomePatient CarePatientsPeptidylprolyl IsomerasePharmaceutical PreparationsPharmacogenomicsPhasePhenotypePopulationPredispositionProteinsPublic HealthRecombinantsRelative (related person)RepliconResearchResearch DesignResearch MethodologyResistanceResistance developmentResourcesRibavirinRoleSamplingSerumSiteSolidStagingSystemTestingTherapeuticTimeTransfusionTransplant RecipientsTransplantationUnited StatesUnited States Department of Veterans AffairsVariantVeteransVietnamViralViral Nonstructural ProteinsViral ProteinsViral Regulatory ProteinsViremiaVirusanti-hepatitis Cbaseburden of illnesscombatcostcyclophilin Beffective therapyfitnessfunctional genomicshigh riskimprovedin vivoinhibitor/antagonistinsightliver transplantationmortalitymutantpathogenpre-clinicalpressurepreventprotein foldingpublic health relevanceresponserisk benefit ratiosmall moleculetreatment responsetreatment strategyviral resistancevirus genetics

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Genotyping and Phenotyping the Hepatitis C Drug Target NS5A
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