2015 Hormone-Dependent Cancers Gordon Research Conference and Gordon Research Seminar

2015年激素依赖性癌症戈登研究会议及戈登研究研讨会

• 批准号: 8907254
• 负责人: Matthew J Sikora
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8907254
• 关键词: Academia; Accounting; Address; Automobile Driving; Back; Basic Science; Binding; Biological Models; Biology; Cancer Etiology; Cessation of life; Clinic; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Coupled; Creativeness; Dedications; Development; Discipline; Disease; Disease Progression; Doctor of Philosophy; Endocrine; Endometrium; Ensure; Environment; Etiology; Evolution; Federal Government; Fertilization; Foundations; Future; Goals; Health; Heterogeneity; Hormone Receptor; Hormones; Human; Industry; Laboratories; Lead; Ligands; Malignant Neoplasms; Malignant neoplasm of liver; Malignant neoplasm of lung; Malignant neoplasm of ovary; Malignant neoplasm of prostate; Metastatic to; Modeling; Molecular; Morbidity - disease rate; Mutation; Neoplasm Metastasis; Oral; Outcome; Participant; Pathway interactions; Patient Care; Patients; Phenotype; Phosphotransferases; Physicians; Postdoctoral Fellow; Request for Proposals; Research; Research Personnel; Resistance; Scientist; Senior Scientist; Signal Pathway; Signal Transduction; Solid Neoplasm; Structure; Testing; Testis; Therapeutic; Time; Translational Research; United States; Work; abstracting; anticancer research; cancer diagnosis; cancer genome; cancer initiation; cancer therapy; career; career development; collaborative environment; design; drug candidate; drug development; epigenome; extracellular; functional genomics; graduate student; hormone therapy; improved; malignant breast neoplasm; meetings; mortality; next generation; novel; outreach program; posters; public health relevance; receptor; response; symposium; targeted treatment; therapeutic target; tumor

 DESCRIPTION (provided by applicant): Hormone-dependent cancers represent a major component of morbidity and mortality caused by malignancies. Two such diseases, prostate and breast cancer, will account for ~465,000 cancer diagnoses and nearly ~70,000 deaths in 2014 in the US. Further, hormones drive other cancers (ovary, testes, endometrium), and influence the etiology of lung and liver cancer. Developing better treatments for these cancers is critical, given their dramatic impact on human health. To address this, the goal of the 2015 Gordon Research Conference (GRC) "Hormone-Dependent Cancers", entitled "Mechanisms to tailored therapeutics", is to encourage interaction and exchange of ideas to fuel new projects and collaborations across disciplines, identify translational opportunities, and create improved therapies targeting hormone-dependent cancers. The 2015 meeting is designed to maximize interaction among participants, in order to engender creativity and cross-fertilization of ideas across scientists and clinicians from academia and industry, with basic, translational, and clinical research expertise. Integrating these disciplines, coupled with the intimate, open and collaborative environment of GRC meetings, is an important and unique strength of this meeting. This meeting will bring together basic scientists with translational researchers, industry scientists, and physician-scientists that can apply new findings to novel model systems, lead drug development, and test new clinical strategies. Novel observations from the clinic can be brought back to the laboratory to identify new targetable pathways. This is the only GRC meeting that integrates basic, translational, and clinical aspects of multiple solid tumors. The 2015 GRC is also unique in its dedication to the development of the next generation of scientists, via a new Gordon Research Seminar (GRS), entitled "Bridging research in hormone response and resistance in cancer". Held prior to the GRC, the GRS is a unique forum specifically for early-career researchers (ECRs; graduate students, post-docs, and clinical fellows). The GRS is a novel format that will build the foundation of the future community of scientists studying hormone-dependent cancer. This proposal requests support specifically for ECRs, so that no ECR is excluded from attending for financial constraints. Overall, this meeting will generate new ideas and collaborative projects, and identify the translational opportunities that can ultimately lead to improved therapies. This unique environment will develop the future leaders of this field, ensuring continued progress in advancing our understanding the biology of hormone- dependent cancers and improving patient outcomes.

 描述（由申请方提供）：激素依赖性癌症是恶性肿瘤引起的发病率和死亡率的主要组成部分。2014年，在美国，前列腺癌和乳腺癌这两种疾病将导致约465，000例癌症诊断和近70，000例死亡。此外，激素驱动其他癌症（卵巢癌，睾丸癌，子宫内膜癌），并影响肺癌和肝癌的病因。鉴于这些癌症对人类健康的巨大影响，开发更好的治疗方法至关重要。为了解决这个问题，2015年戈登研究会议（GRC）“激素依赖性癌症”的目标，题为“定制治疗的机制”，是鼓励互动和思想交流，以推动新项目和跨学科合作，确定转化机会，并创建针对激素依赖性癌症的改进疗法。2015年的会议旨在最大限度地提高与会者之间的互动，以产生创造力和跨学科的想法，科学家和临床医生从学术界和工业界，与基础，转化和临床研究的专业知识。整合这些学科，再加上GRC会议的亲密，开放和协作环境，是本次会议的一个重要和独特的优势。这次会议将汇集基础科学家与翻译研究人员，工业 科学家和医生科学家，可以将新发现应用于新的模型系统，领导药物开发，并测试新的临床策略。临床上的新观察结果可以带回实验室，以确定新的靶向途径。这是唯一一个整合了多种实体瘤的基础、转化和临床方面的GRC会议。2015年GRC的独特之处还在于，它通过新的戈登研究研讨会（GRS）致力于培养下一代科学家，该研讨会题为“癌症激素反应和耐药性的桥梁研究”。在GRC之前举行，GRS是专门为早期职业研究人员（ECR;研究生，博士后和临床研究员）提供的独特论坛。GRS是一种新的形式，将为未来研究依赖癌症的科学家社区奠定基础。该提案要求专门为教育委员会代表提供支助，以便任何教育委员会代表都不会因财政拮据而无法出席会议。总的来说，这次会议将产生新的想法和合作项目，并确定最终可以改善治疗的转化机会。这种独特的环境将培养该领域的未来领导者，确保在推进我们对激素依赖性癌症生物学的了解和改善患者预后方面取得持续进展。