Integrated Training in Reproductive Sciences

项目摘要/摘要 该培训计划为从事生殖生物学研究工作的医生和科学家做准备。 在其30年的历史中，该项目已培训了90名博士后研究员和研究生，他们拥有 在学术界和工业界取得了成功的职业生涯。该计划是多方面的，基础广泛。 研究培训由生殖科学中心(CRS)的23名成员提供，他们是教师 在8个部门和组织了研究单位的职位。该学院有广泛的科学研究领域 生殖生物学方面的专门知识和活动，包括：干细胞生物学、生殖细胞发育、减数分裂、 卵泡成熟，激素作用机制，分子遗传学，类固醇生物合成和作用， 子宫内膜和胎盘功能，生殖功能正常和异常的内分泌调节，基础 和多囊卵巢综合征的临床研究。可用的技术包括：人类和小鼠胚胎学、胚胎和 诱导多能干细胞，转基因小鼠，果蝇干细胞和生殖细胞发育，酵母模型 减数分裂，人类遗传学和基因组学，最新的DNA和RNA测序，蛋白质/核酸 相互作用技术、微阵列和蛋白质组学、生物信息学、蛋白质的质谱学分析 小分子、尖端显微镜和成像技术、体外受精、整个动物 生理学，前瞻性临床研究。在正式申请CRS(博士后研究员)或 对于适当的研究生项目(博士前研究员)，受训者由招生委员会挑选。 研究生继续攻读博士学位的课程。将提供博士后培训 授予相关学科的博士研究生，以及经过专业训练的临床医学博士科学家。在……里面 除了研究工作，学员还参加规定的学术课程、研讨会、期刊俱乐部、 关于负责任的研究行为的会议和研讨会。学员学习设计和执行 基础研究项目，分析数据，为著名同行评议期刊撰写稿件。实习生 准备和提交校外资金的拨款申请，举办生殖生物学研讨会，以及 学习如何指导暑期在实验室工作的学生，为他们独立学习做好准备 事业。学员的学术发展由指导委员会通过个人发展来保证 计划；通过对校友的调查来跟踪学员和培训计划的成功情况。的优势所在 计划包括1。)教师的不同技能和兴趣，2.)教职员工的互动性。)我们的 大量实验室和核心设施资源。)生殖研究的优秀环境， 加州大学旧金山分校的发育、内分泌学、细胞生物学、遗传学和相关领域。对美国政府的承诺 科学界的最高行为标准。

PROJECT SUMMARY/ABSTRACT This Training Program prepares physicians and scientists for investigative careers in reproductive biology. During its 30 year history, the program has trained 90 postdoctoral fellows and graduate students who have gone on to successful careers in academia and industry. The program is multifaceted and broadly based. Research training is provided by 23 members of the Center for Reproductive Sciences (CRS) who hold faculty positions in 8 departments and organized research units. The Faculty have a broad range of scientific expertise and activities in reproductive biology, including: stem cell biology, germ cell development, meiosis, follicular maturation, mechanisms of hormone action; molecular genetics, steroid biosynthesis and action, endometrial and placental function, endocrine regulation of normal and abnormal reproductive function, basic and clinical studies of PCOS. Technologies available include: human and mouse embryology, embryonic and induced pluripotent stem cells, transgenic mice, drosophila stem and germ cell development, yeast models of meiosis, human genetics and genomics, state-of-the-art DNA and RNA sequencing, protein/nucleic acid interaction technologies, microarrays and proteomics, bioinformatics, mass spectrometric analysis of proteins and small molecules, cutting edge microscopy and imaging technologies, in vitro fertilization, whole animal physiology, prospective clinical investigation. Following formal application to the CRS (postdoctoral fellows) or to an appropriate graduate program (predoctoral fellows), trainees are selected by an Admissions Committee. Graduate students pursue a course of study leading to the Ph.D. degree. Postdoctoral training will be offered to Ph.D. fellows in related disciplines, and to clinically trained M.D. scientists with prior specialty training. In addition to their research work, trainees take prescribed academic courses, seminars, journal clubs, conferences, and seminars on the responsible conduct of research. Trainees learn to design and execute basic research projects, analyze data and write manuscripts for prominent peer-reviewed journals. Trainees prepare and submit grant applications for extra-mural funding, present seminars in reproductive biology, and learn how to mentor students working in the lab during the summer, preparing them for independent academic careers. Trainee academic development is assured by mentoring committees through individual development plans; success of trainees and the training program is tracked through surveys of alumni. The strengths of the program include 1.) the diverse skills and interests of the faculty, 2.) the interactiveness of the faculty 3.) our substantial laboratory and core facility resources 4.) the outstanding environment for research in reproduction, development, endocrinology, cell biology, genetics and related areas at UCSF and 5.) the commitment to the highest standard of conduct in science.