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Novel Ca receptor signaling pathways for control of renal ion transport

Novel Ca receptor signaling pathways for control of renal ion transport
控制肾离子转运的新型 Ca 受体信号通路
批准号：
8195579
负责人：
Richard Tyler Miller
金额：
$0.0万
依托单位：
LOUIS STOKES CLEVELAND VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-04-01 至 2014-06-30
来源：
https://reporter.nih.gov/project-details/8195579
关键词：
AffectBartter DiseaseBicarbonatesBiochemicalBiotinylationBloodBlood PressureBody FluidsCalciumCalcium-Sensing ReceptorsCardiovascular systemCarrier ProteinsCell CommunicationCell surfaceCellsCharacteristicsCloningComplications of Diabetes MellitusCoupledCultured CellsDataDiseaseDistalDominant-Negative MutationEdemaEnzymesEpithelial CellsFamilyG-Protein-Coupled ReceptorsGTP-Binding ProteinsGoalsHealthHeart DiseasesHematological DiseaseHereditary DiseaseHeterotrimeric GTP-Binding ProteinsHypercalcemiaHypertensionHypotensionIntracellular Second MessengerIon TransportIonsKidneyKidney DiseasesLeadLocationMDCK cellMeasurementMeasuresMembraneMembrane Transport ProteinsMinorModelingMutationNephronsPathologicPathway interactionsPatientsPhenotypePhosphoproteinsPhosphotransferasesPhysiologicalPopulationPotassium ChannelProcessProteinsReceptor ActivationReceptor SignalingRegulationRenal GlycosuriaRisk FactorsRunningScaffolding ProteinSecond Messenger SystemsSignal PathwaySignal TransductionSignaling ProteinSmall Interfering RNASodium ChlorideStrokeSurfaceSystemTestingTwo-Hybrid System TechniquesUrineVariantVascular DiseasesVeteransWaterXenopus oocyteYeastsadverse outcomeapical membranebasebasolateral membraneblood pressure regulationbody volumeclinically significantdensityextracellularimprovedin vivoinward rectifier potassium channelkidney cellloss of function mutationmonolayermutantnovelprotein transportreceptorresearch studyresponseyeast two hybrid system

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