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Mechanisms of Tyrosine Kinase Inhibitor Resistance in GI Stromal Tumors

Mechanisms of Tyrosine Kinase Inhibitor Resistance in GI Stromal Tumors
胃肠道间质瘤酪氨酸激酶抑制剂耐药机制
批准号：
8195870
负责人：
Michael C Heinrich
金额：
$0.0万
依托单位：
PORTLAND VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-04-01 至 2013-04-01
来源：
https://reporter.nih.gov/project-details/8195870
关键词：
AccountingAcute Myelocytic LeukemiaAdultAdverse effectsAdverse reactionsAgeAllelesAmericanApoptosisBAY 54-9085BiochemicalBiological AssayBiological ModelsBudgetsCancer BiologyCaringCell LineCell modelCellsChinese Hamster Ovary CellClinicalClinical TrialsCloningColon CarcinomaCombined Modality TherapyComorbidityCytoplasmic TailCytotoxic agentDNADasatinibDevelopmentDiabetes MellitusDiagnosisDrug resistanceEffectivenessEthylnitrosoureaFrequenciesGastrointestinal Stromal TumorsGenomicsGenotypeHealthHealthcareHigh Pressure Liquid ChromatographyHospitalizationImatinibIn VitroInvestigationLaboratoriesLifeMaintenanceMalignant NeoplasmsMalignant neoplasm of lungMalignant neoplasm of prostateMass Spectrum AnalysisMeasurementModelingMorbidity - disease rateMucositisMutagenesisMutationNeutropenic FeverOncogenicPDGFRA genePathway interactionsPatientsPatternPharmaceutical PreparationsPhosphorylationPhosphotransferasesPlayPrincipal InvestigatorPulmonary Heart DiseaseQuality of lifeRadiationReceptor Protein-Tyrosine KinasesRecurrenceResearchResistanceRiskRoleSeminomaSignal TransductionSignaling MoleculeSolid NeoplasmSpecimenSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationStromal NeoplasmSystemTechniquesTestingTherapeutic AgentsTimeToxic effectTransfectionTreatment outcomeTumor BiologyTyrosine Kinase InhibitorUnresectableVariantVeteransadvanced diseasebasecancer carecancer therapychemotherapyclinically relevantconventional therapycostextracellularimprovedinhibitor/antagonistinsightkinase inhibitormalignant breast neoplasmmastocytosismedical complicationmelanomamortalitymutantnovelnovel therapeuticspreventprogramsresearch studyresistance mechanismsarcomasmall moleculesoft tissuetreatment strategytumortumor progression

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