Modeling Immunity for Biodefense: Influenza virus

生物防御免疫建模：流感病毒

• 批准号: 8159582
• 负责人: STUART SEALFON
• 金额: $ 1721.96万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8159582
• 关键词: Address; Antiviral Response; Bioinformatics; Cells; Communities; Complex; Computer Simulation; Contracts; Data; Data Set; Databases; Dendritic Cells; Development; Environment; Genetic; Genetic Polymorphism; Human; Immune; Immune response; Immunity; Immunology; Individual; Infection; Influenza A Virus, H1N1 Subtype; Integration Host Factors; Knowledge; Link; Measurement; Modeling; Outcome; Pathway interactions; Physiological; Process; Research; Research Support; Schools; Shapes; Signal Transduction; Testing; Variant; Virus; Virus Diseases; adaptive immunity; base; biodefense; cytokine; improved; influenzavirus; mathematical model; model development; pandemic disease; paracrine; pathogen; predictive modeling; programs; response; symposium; tool; user-friendly; viral detection

The Modeling Immunity for Biodefense Program supports research to create new or improved mathematical models that are able to generate knowledge from standard or complex datasets and guide further experimentation to advance the study of immunology or immune-based therapies. The program also supports accompanying immunological experimentation to provide the data required for model development and testing. Specifically, the scope of activities includes: ¿ Development and refinement of mathematical and computational models to be used for knowledge discovery through integration and analysis of complex and/or standard datasets. ¿ Assessment of model functionality thought the iterative process, requiring the acquisition of quantitative immunological measurement for developing, testing, validating, and refining the computational models. ¿ Establishment of a bioinformatics component to maintain a database of immunological data and develop immune modeling tools. ¿ Development of an educational component consisting of summer school programs and symposia for the broader research community to promote the use of mathematical and computational modeling in studies of immune responses to infection or immune-based therapies.

生物防御免疫建模计划支持创建新的或改进的数学模型的研究，这些模型能够从标准或复杂的数据集中生成知识，并指导进一步的实验，以推进免疫学或基于免疫的疗法的研究。该计划还支持随附的免疫学实验，以提供模型开发和测试所需的数据。具体来说，活动范围包括： ¿ 通过复杂和/或标准数据集的集成和分析，开发和完善用于知识发现的数学和计算模型。 ?? 模型功能的评估是迭代过程，需要获取定量免疫学测量来开发、测试、验证和完善计算模型。 ¿ 建立生物信息学组件来维护免疫数据数据库并开发免疫建模工具。 ¿ 为更广泛的研究界开发一个由暑期学校项目和研讨会组成的教育部分，以促进数学和计算模型在感染或基于免疫疗法的免疫反应研究中的使用。