TAS::75 0872::TAS SCREENING AND CONFIRMATORY TESTS FOR HUMAN BABESIA SBIR PHASE

TAS::75 0872::TAS 人类巴贝斯虫 SBIR 阶段筛选和确认测试

• 批准号: 8165215
• 负责人: ANDREW LEVIN
• 金额: $ 21.75万
• 依托单位: IMMUNETICS, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2011-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8165215
• 关键词: Babesia; Babesiosis; Biological Assay; Bite; Blood Screening; Blood Transfusion; Borrelia microti; Cessation of life; Characteristics; Deer Tick; Development; Elderly; Enzyme Immunoassay; Erythrocytes; Human; Individual; Infection; Malaria; Methods; Parasites; Phase; Reporting; Risk; Sensitivity and Specificity; Serological; Small Business Innovation Research Grant; Testing; Transfusion; United States; immunosuppressed; prototype

Human babesiosis is a malaria-like illness due to infection of red blood cells by various species of protozoan parasites belonging to the genus Babesia. Most human infections reported in the United States are caused by B. microti which is endemic in parts of the northeast and north central United States. B. microti infections are often asymptomatic but can also progress to severe illness and even death, particularly in individuals who are immunosuppressed, asplenic or elderly. The parasite is transmitted primarily by the bite of the deer tick, however, it can also be transmitted by blood transfusion. More than 60 cases of transfusion-transmitted babesiosis have been identified over the last 40 years. During the past four years, there has been an alarming increase in the number of deaths due to transfusion-transmitted babesiosis. Hence, there is an urgent need to minimize the risk through development and implementation of a method for blood screening for Babesia.

人类巴贝斯虫病是一种类似疟疾的疾病，由于红细胞被属于巴贝斯虫属的各种原生动物寄生虫感染。美国报告的大多数人类感染是由B引起的。在美国东北部和中北部的部分地区特有的一种田鼠属。B。Microti感染通常无症状，但也可发展为严重疾病，甚至死亡，特别是在免疫抑制、无脾或老年人中。这种寄生虫主要通过鹿蜱的叮咬传播，然而，它也可以通过输血传播。在过去的40年里，已经发现了60多例输血传播的巴贝虫病。在过去四年中，由于输血传播的巴贝虫病而死亡的人数惊人地增加。因此，迫切需要通过开发和实施一种用于血液筛查巴贝妥的方法来最大限度地降低风险。