Immunobiology of Blood and Vascular Systems Training Program

描述(由申请人提供)：此续签申请的重新提交请求继续支持范德比尔特大学血液和血管系统免疫生物学(IBVSTP)的成熟、充满活力和富有成效的培训计划。IBVSTP专注于将炎症作为疾病的主要机制，这些疾病显著改变血液和血管系统，以应对各种微生物、自身免疫和代谢侮辱。这一创新的培训平台用于指导包括双学位学生和博士后研究员在内的研究生和博士后的职业发展，并从代表8个基础科学和临床系的21名教员研究人员的快速增长的卓有成效的合作和由此产生的出版物中证明了其有效性。这一名册使IBVSTP能够促进将炎症介导性疾病的细胞和分子研究转化为创新疗法的临床前研究。自成立以来，我们为教师和受训者之间的有效互动提供了一个迄今尚不存在的平台，这些主题包括：(1)脓毒症和肺部/心血管感染中的先天免疫和炎症；(2)动脉粥样硬化、自身免疫、高血压、代谢综合征和移植中的促炎T和B淋巴细胞信号和基因表达；(3)造血细胞的发育、运输和黏附；(4)炎症和自身免疫中的细胞外基质模拟；以及(5)功能基因组学、表观遗传学、蛋白质组学、结构生物学和蛋白质组修复中的细胞内肽/蛋白递送。 心理治疗。自2006年上一次更新以来，这些概念性和尖端技术资源为14名博士后和19名博士后实习生提供了增强实践研究经验和职业发展的巨大机会，其中包括来自代表性不足群体的学员。该计划的旗舰课程“功能基因组学和蛋白质组学：免疫生物学的应用”提供了统一的教学平台。负责任的研究行为机构课程由特定于项目的讨论小组补充。通过申请5个博士后和5个博士后实习生名额，我们满足了学术界日益增长的培训需求。IBVSTP指导委员会对培训候选人的选择采用严格的录取标准，包括强调拟议项目的翻译目标，并评估学员的表现。拥有博士和/或医学博士学位的博士后实习生经过IBVSTP指导委员会的审查后被任命，并由代表该计划亲和力小组的指导团队提供建议。外部顾问和顾问的投入以及学员的持续反馈提供了额外的培训质量检查点，增强了该计划在基础、翻译和临床研究方面为下一代研究人员做准备的强劲记录，这些研究侧重于炎症是影响血液和血管系统的疾病的主要机制。

DESCRIPTION (provided by applicant): This resubmission of the renewal application requests continued support for a well-established, vibrant and productive Training Program in the Immunobiology of Blood and Vascular Systems (IBVSTP) at Vanderbilt University. IBVSTP is focused on inflammation as the major mechanism of diseases that significantly alter blood and vascular systems in response to diverse microbial, autoimmune, and metabolic insults. This innovative training platform for mentoring and career development of graduate students, including dual degree students, and postdoctoral fellows has proven its effectiveness as attested by a rapidly growing number of fruitful collaborations and resulting publications from 21 faculty investigators who represent 8 basic science and clinical departments. This roster allows IBVSTP to facilitate translation of cellular and molecular studies of inflammation-mediated disorders into preclinical studies of innovative therapies. Since its inception, a hitherto non-existent platform was formed for effective interactions of faculty preceptors and trainees within thematic "affinity groups" encompassing: (1) Innate immunity and inflammation in sepsis and pulmonary/cardiovascular infections; (2) Proinflammatory T and B lymphocyte signaling and gene expression in atherosclerosis, autoimmunity, hypertension, metabolic syndrome, and transplantation; (3) Hemopoietic cell development, trafficking, and adhesion; (4) Extracellular matrix modeling in inflammation and autoimmunity; and (5) Functional genomics, epigenetics, proteomics, structural biology, and intracellular peptide/protein delivery for proteome restoration therapy. Since its prior renewal in 2006, these conceptual and cutting edge technological resources have provided tremendous opportunities for enhanced hands-on research experience and career development to 14 predoctoral and 19 postdoctoral trainees, including those from underrepresented groups. The Program's flagship course "Functional Genomics and Proteomics: Applications to Immunobiology" provides the unifying didactic platform. The institutional course on Responsible Conduct of Research is complemented by the Program-specific discussion groups. By requesting 5 predoctoral and 5 postdoctoral trainee slots, we respond to a growing demand for training from the Academic Community. The IBVSTP Steering Committee applies stringent admission criteria for selection of training candidates, including emphasis on translational goals of proposed projects, and evaluates trainees' performance. Postdoctoral trainees with Ph.D. and/or M.D. degrees are appointed following review by the IBVSTP Steering Committee and are advised by mentoring teams that represent the Program's Affinity Groups. The input of External Advisors and Consultants and a continuing feedback from trainees provide additional training quality checkpoints that enhance the Program's strong record of preparing the next generation of investigators in fundamental, translational, and clinical research focused on inflammation as the major mechanism of diseases affecting blood and vascular systems.