Real time and noninvasive monitoring of blood flow during surgery

描述（由申请人提供）：如果外科医生能够获得其术野中血流的即时信息，则进行复杂血管手术（如动脉瘤夹闭术）的外科医生将受益。能够以高分辨率监测血流的当前技术要么使用复杂的专用设备，要么依赖于造影剂的施用，这两者对外科手术都是破坏性的，因此是不期望的。我们提出了一种新的方法，可以非侵入性地提供真实的实时信息的血流在外科医生的视野中的空间尺度的微血管。这种模块化光学成像系统（称为SurgeON TM）将与手术室中现有的手术显微镜集成，以适度的成本负担增加关键的血流监测能力。该补充血流信息将使用专有和许可的激光散斑对比度成像技术获得，并且可选地在外科医生的视野中呈现给外科医生，覆盖在感兴趣区域上。 我们的第一阶段工作包括设计SurgeON系统以实时获得高分辨率血流信息，并在大脑中动脉手术闭塞期间测试其在替代动物模型中术中使用的可行性。具体而言，SurgeON系统将利用一种在现场可编程门阵列（FPGA）上高速处理激光散斑数据的新方法，减少了真实的时间信息可用的延迟，同时优化了空间和时间分辨率的折衷。如果成功，我们预计将开展第二阶段项目，在此期间，我们将开发临床级SurgeON系统，并研究其在神经外科临床中的性能和实用性。虽然I期和II期工作的重点是神经外科，因为高分辨率血流信息在大脑中的重要性，但通过将标准手术显微镜转换为先进的血流测量显微镜，SurgeON系统将在所有手术中发挥潜在的促进作用。

DESCRIPTION (provided by applicant): Surgeons performing complex vascular surgeries as aneurysm clipping could benefit if instantaneous information on blood flow in their surgical field was made available to them. Current technologies that can monitor blood flow at high resolution either engage complex dedicated equipment or rely on administration of contrast agents, both of which are disruptive to the surgical procedure and hence, undesired. We propose a novel method that can noninvasively provide real time live information about blood flow in the surgeon's field of view at the spatial scale of microvessels. This modular optical imaging system (called the SurgeONTM) will integrate with existing surgical microscopes in operating rooms to add the crucial blood flow monitoring capability at a modest cost burden. This complementary blood flow information will be obtained using proprietary and licensed laser speckle contrast imaging technology, and optionally presented to the surgeon in his/her visual field overlaid on the region of interest. Our Phase I effort comprises of engineering the SurgeON system to obtain high resolution blood flow information in real-time and testing the feasibility of its intraoperative use in a surrogate animal model during the surgical occlusion of the middle cerebral artery. Specifically, the SurgeON system will utilize a novel method of high speed processing of laser speckle data on a field programmable gate array (FPGA) reducing the latency with which real time information may be available while optimizing the compromise in spatial and temporal resolution. If successful, we anticipate undertaking a Phase II project, during which we will develop a clinical grade SurgeON system and investigate its performance and utility in the clinic during neurosurgery. While the focus of the Phase I and II efforts is on neurosurgery due to crucial nature of high-resolution blood flow information in the context of the brain, the SurgeON system will potentially play an enabling role in all surgeries by converting a standard surgical microscope to an advanced blood flow measuring microscope.