Bioengineering and Bioimaging Core

项目主任/首席调查员(最后、第一、中间)：Vyavahare，Naren 项目摘要：生物工程和生物成像核心 生物工程和生物成像核心(B5)由四个推力领域组成，每个领域都是 对组织工程、再生医学和药物输送系统的支持至关重要 研究方向：生物材料表征、生物活性基质合成及生物反应器设计、 生物力学和生物成像。B5将与目标Cobre PI和外部调查人员合作 协助他们策划和进行研究，以及分析他们在 这四个推力领域中的每一个。核心提供了最先进的设施，这是 个人调查人员的实验室。这些设施包括Waters的高效液相色谱系统；PerkinElmer 分析200火焰原子吸收光谱仪；JASCO J-810圆二色仪 光谱偏振仪；Sopra GES-5型可变角光谱椭偏仪；Biacore X表面 等离子共振光谱仪；克鲁斯接触角测角仪；SAHAGE MFP-3D-BIO原子仪 力显微镜；定制设计的多功能生物反应器系统；广泛的生物力学 具有多轴和环境室能力的硬组织和软组织测试系统；以及 一套活体生物成像系统，包括数字放射成像、超声、IVIS Lumina XR系统 (荧光、生物发光成像和X射线相结合)和Quantum FX MicroCT(待定 购买)。B5将为每个设施配备有经验的主管和支持人员， 谁将负责核心仪器的维护，谁将提供专用用户 培训和支持。作为Cobre系统中唯一的核心(来自&gt；200)，专注于生物工程和 生物成像，这个核心是科布雷中心的重要组成部分，它将提供无价的 为目标-PI以及组织工程领域的外部调查人员提供服务和支持， 再生医学，药物输送系统设计。 OMB编号0925-0001/0002(08/12版批准至2015年8月31日)页面续格式页面

Program Director/Principal Investigator (Last, First, Middle): Vyavahare, Naren Project Summary: The Bioengineering and Bioimaging Core The Bioengineering and Bioimaging Core (B5) is composed of four thrust areas, each of which are of critical importance for the support of tissue engineering, regenerative medicine, and drug delivery system research: Biomaterials Characterization, Bioactive Matrix Synthesis and Bioreactor Design, Biomechanics, and Bioimaging. The B5 will work with the targeted COBRE PIs and outside investigators to assist them with planning and conducting their research and in the analysis of their research results in each of these four thrust areas. The Core provides state-of-the-art facilities not normally available in the laboratories of individual investigators. These facilities include a Waters HPLC system; a PerkinElmer Analysis 200 flame atomic absorption spectrophotometer; a JASCO J-810 circular dichroism spectropolarimeter; a SOPRA GES-5 variable angle spectroscopic ellipsometer; a Biacore X surface plasmon resonance spectrometer; a Kruss contact angle goniometer; an Asylum MFP-3D-BIO atomic force microscope; a custom designed multi-functional bioreactor systems; a broad range of biomechanical testing systems for both hard and soft tissues with multiaxial and environmental chamber capabilities; and a suite of in vivo bioimaging systems including digital radiography, ultrasound, IVIS Lumina XR system (fluorescence, bioluminescence imaging and X-ray combined), and Quantum FX microCT (to be purchased). The B5 will staff each of these facilities with experienced supervisors and support personnel, who will be responsible for the maintenance of the Core instruments and who will provide dedicated user training and support. As the only core in the COBRE system (out of > 200) focused on bioengineering and bioimaging, this core represents a vital component of the COBRE Center, which will provide invaluable service and support for the target-PIs as well as outside investigators working in tissue engineering, regenerative medicine, and drug delivery system design. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page