Bioengineering and Bioimaging Core

项目负责人/主要研究者（最后，第一，中间）：Vyavahare，Naren 项目摘要：生物工程和生物成像核心 生物工程和生物成像核心（B5）由四个推力区域组成，每个区域都是 对支持组织工程、再生医学和药物输送系统至关重要 研究：生物材料表征，生物活性基质合成和生物反应器设计， 生物力学和生物成像。B5将与目标COBRE PI和外部调查人员合作 协助他们规划和开展研究，并分析他们的研究成果， 这四个推力区域中的每一个。核心区提供了一般城市所没有的最先进的设施。 个人研究者的实验室。这些设施包括沃茨HPLC系统; PerkinElmer 解析200火焰原子吸收分光光度计; JASCO J-810圆二色 分光偏振计; SOPRA GES-5可变角分光椭圆偏振计; Biacore X表面 等离子体共振光谱仪; Kruss接触角测角仪; Asylum MFP-3D-BIO原子吸收光谱仪 力显微镜;定制设计的多功能生物反应器系统;广泛的生物力学 用于硬组织和软组织的测试系统，具有多轴和环境室能力;以及 一套体内生物成像系统，包括数字X射线摄影、超声、IVIS Lumina XR系统 （荧光，生物发光成像和X射线相结合），和量子FX microCT（将 购买）。B5将为每个设施配备经验丰富的主管和支持人员， 谁将负责核心仪器的维护，谁将提供专门的用户 培训和支持。作为COBRE系统（超过200个）中唯一专注于生物工程的核心， 生物成像，这个核心代表了COBRE中心的重要组成部分，这将提供宝贵的 为目标PI以及在组织工程领域工作的外部研究者提供服务和支持， 再生医学和药物输送系统设计。 OMB编号0925-0001/0002（2012年8月批准至2015年8月31日修订版）页码续页格式页码

Program Director/Principal Investigator (Last, First, Middle): Vyavahare, Naren Project Summary: The Bioengineering and Bioimaging Core The Bioengineering and Bioimaging Core (B5) is composed of four thrust areas, each of which are of critical importance for the support of tissue engineering, regenerative medicine, and drug delivery system research: Biomaterials Characterization, Bioactive Matrix Synthesis and Bioreactor Design, Biomechanics, and Bioimaging. The B5 will work with the targeted COBRE PIs and outside investigators to assist them with planning and conducting their research and in the analysis of their research results in each of these four thrust areas. The Core provides state-of-the-art facilities not normally available in the laboratories of individual investigators. These facilities include a Waters HPLC system; a PerkinElmer Analysis 200 flame atomic absorption spectrophotometer; a JASCO J-810 circular dichroism spectropolarimeter; a SOPRA GES-5 variable angle spectroscopic ellipsometer; a Biacore X surface plasmon resonance spectrometer; a Kruss contact angle goniometer; an Asylum MFP-3D-BIO atomic force microscope; a custom designed multi-functional bioreactor systems; a broad range of biomechanical testing systems for both hard and soft tissues with multiaxial and environmental chamber capabilities; and a suite of in vivo bioimaging systems including digital radiography, ultrasound, IVIS Lumina XR system (fluorescence, bioluminescence imaging and X-ray combined), and Quantum FX microCT (to be purchased). The B5 will staff each of these facilities with experienced supervisors and support personnel, who will be responsible for the maintenance of the Core instruments and who will provide dedicated user training and support. As the only core in the COBRE system (out of > 200) focused on bioengineering and bioimaging, this core represents a vital component of the COBRE Center, which will provide invaluable service and support for the target-PIs as well as outside investigators working in tissue engineering, regenerative medicine, and drug delivery system design. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page