Networks Underlying Visual Modulation of Speech Perception

语音感知视觉调制的网络基础

• 批准号: 9337601
• 负责人: David Brang
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9337601
• 关键词: Accounting; American; Aphasia; Area; Auditory; Auditory area; Autistic Disorder; Brain; Chicago; Cognitive; Cues; Development; Development Plans; Diffusion Magnetic Resonance Imaging; Educational workshop; Electrocorticogram; Electroencephalography; Environment; Epilepsy; Equilibrium; Evaluation; Face Processing; Fusiform gyrus; Goals; Health; Human; Image; Individual; Individual Differences; Knowledge; Language; Leadership; Lip structure; Lipreading; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mentors; Modality; Modeling; Monitor; Movement; Neurology; Noise; Operative Surgical Procedures; Oral cavity; Pathway interactions; Patients; Positioning Attribute; Postdoctoral Fellow; Prevalence; Process; Psychology; Psychophysics; Research; Research Personnel; Scalp structure; Schizophrenia; Scientist; Signal Transduction; Societies; Speech; Speech Perception; Speed; Structure of superior temporal sulcus; Techniques; Testing; Training; Universities; Visual; Visual Motion; Weight; area MT; audiovisual speech; base; career development; clinically relevant; cognitive neuroscience; experience; graduate student; healthy aging; individual patient; language processing; meetings; memory process; multisensory; neuroimaging; novel; programs; research and development; research study; speech processing; support network; symposium; temporal measurement; tenure track; visual information; visual speech

DESCRIPTION (provided by applicant): The proposed research seeks to identify the anatomical and functional networks that support the facilitation of auditory speech processes by visual information. This research line is built on a novel model describing low- and high-level multisensory mechanisms that mediate speech perception processes and is evaluated by anatomical and functional measures of connectivity in typically developing individuals and patients with epilepsy. These aims will be accomplished through a detailed career development plan outlining my training in functional measures of connectivity using electroencephalography (EEG), intracranial electrocorticography (ECoG) in patients with epilepsy, as well as training in rigorous research on speech perception and epilepsy. This training regiment is supported by a team of respected scientists who together have expertise in each aspect of my research and career development plans. Drs. Suzuki and Grabowecky have expertise in auditory- visual multisensory processes including speech perception. Dr. Paller is an esteemed EEG and MRI researcher who has an established record of successfully training graduate students and post-doctoral researchers who advance to tenure-track positions at top Universities. Dr. Leo Towle from the University of Chicago is an established epilepsy researcher and neurophysiologist who uses intracranial ECoG measurements to study memory and language processes. Furthermore, each of these mentors has an excellent track record of administrative and leadership experience: Dr. Grabowecky as former assistant Chair of the Psychology Department, Dr. Paller as the Director of the Cognitive Neuroscience program, Dr. Towle as former Chair of Neurology and President of the American Society of Neurophysiologic Monitoring, and Dr. Suzuki as the Director of the Cognitive Division of the Psychology Department. Training from my mentors will be supplemented by attending four technique-based workshops, four academic conferences each year, as well as weekly meetings with each mentor and scholarly meetings at Northwestern University and the University of Chicago to discuss recent research. The overarching goal for this proposal is to advance my understanding of multisensory and speech related processes in order to conduct leading health-related research and to obtain a tenure-track position at a top research university. Supported by a thorough training regiment, this proposed research will provide a thorough understanding of the mechanisms that support multisensory speech perception and will provide clinically relevant understanding of multisensory processes as a compensatory mechanism.

描述（由申请人提供）：拟议的研究旨在确定支持视觉信息促进听觉语音过程的解剖和功能网络。该研究线建立在一种新的模型上，该模型描述了介导言语感知过程的低水平和高水平多感觉机制，并通过典型发育个体和癫痫患者的连接性解剖和功能测量进行评估。这些目标将通过一个详细的职业发展计划来实现，该计划概述了我在癫痫患者中使用脑电图（EEG），颅内皮层电图（ECoG）进行连接功能测量方面的培训，以及在语言感知和癫痫方面进行严格研究的培训。这个培训团得到了一个受人尊敬的科学家团队的支持，他们在我的研究和职业发展计划的各个方面都有专业知识。Suzuki和Grabowecky博士在包括言语感知在内的听觉-视觉多感官过程方面具有专业知识。Paller博士是一位受人尊敬的EEG和MRI研究人员，他在成功培训研究生和博士后研究人员方面有着良好的记录，这些研究生和博士后研究人员可以在顶尖大学获得终身教职。来自芝加哥大学的Leo Towle博士是一位成熟的癫痫研究者和神经生理学家，他使用颅内ECoG测量来研究记忆和语言过程。此外，这些导师中的每一位都有出色的行政和领导经验记录：Grabowecky博士是心理学系的前助理主席，Paller博士是认知神经科学项目的主任，Towle博士是神经病学的前主席和美国神经生理监测学会的主席，Suzuki博士是心理学系认知部的主任。从我的导师培训将参加四个技术为基础的研讨会，每年四次学术会议，以及每周与每个导师和学术会议在西北大学和芝加哥大学讨论最近的研究补充。这项建议的总体目标是提高我对多感官和言语相关过程的理解，以便进行领先的健康相关研究，并在顶级研究型大学获得终身教职。在一个全面的训练团的支持下，这项拟议的研究将提供对支持多感觉言语感知的机制的全面理解，并将提供对多感觉过程作为补偿机制的临床相关理解。