Networks Underlying Visual Modulation of Speech Perception

描述（由申请人提供）：拟议的研究旨在确定支持视觉信息促进听觉语言过程的解剖和功能网络。这条研究路线是建立在一个新模型上的，该模型描述了介导言语感知过程的低水平和高水平多感觉机制，并通过典型发展个体和癫痫患者的连接的解剖和功能测量进行了评估。这些目标将通过详细的职业发展计划来实现，该计划概述了我在使用脑电图（EEG）、癫痫患者颅内皮质电图（ECoG）进行连接功能测量方面的培训，以及在语言感知和癫痫方面的严格研究方面的培训。这个训练团由一群受人尊敬的科学家提供支持，他们在我的研究和职业发展计划的各个方面都有专业知识。Drs。铃木和格拉博韦基在包括语言感知在内的听觉-视觉多感觉过程方面具有专长。帕勒博士是一位受人尊敬的脑电图和核磁共振研究人员，他在成功培养研究生和博士后研究人员方面有着良好的记录，这些研究人员在顶尖大学晋升为终身教职。来自芝加哥大学的Leo Towle博士是一位成熟的癫痫研究人员和神经生理学家，他使用颅内ECoG测量来研究记忆和语言过程。此外，这些导师中的每一位都有出色的管理和领导经验：Grabowecky博士是前心理学系助理主席，Paller博士是认知神经科学项目主任，Towle博士是前神经病学主席和美国神经生理监测学会主席，Suzuki博士是心理学系认知部主任。导师的培训将通过参加四个基于技术的研讨会，每年四个学术会议，以及与每个导师的每周会议和西北大学和芝加哥大学的学术会议来补充，以讨论最近的研究。这项提案的总体目标是提高我对多感官和语言相关过程的理解，以便进行领先的健康相关研究，并获得顶尖研究型大学的终身职位。在一个完整的训练团队的支持下，这项拟议的研究将提供对支持多感觉言语知觉的机制的全面理解，并将提供对多感觉过程作为补偿机制的临床相关理解。

DESCRIPTION (provided by applicant): The proposed research seeks to identify the anatomical and functional networks that support the facilitation of auditory speech processes by visual information. This research line is built on a novel model describing low- and high-level multisensory mechanisms that mediate speech perception processes and is evaluated by anatomical and functional measures of connectivity in typically developing individuals and patients with epilepsy. These aims will be accomplished through a detailed career development plan outlining my training in functional measures of connectivity using electroencephalography (EEG), intracranial electrocorticography (ECoG) in patients with epilepsy, as well as training in rigorous research on speech perception and epilepsy. This training regiment is supported by a team of respected scientists who together have expertise in each aspect of my research and career development plans. Drs. Suzuki and Grabowecky have expertise in auditory- visual multisensory processes including speech perception. Dr. Paller is an esteemed EEG and MRI researcher who has an established record of successfully training graduate students and post-doctoral researchers who advance to tenure-track positions at top Universities. Dr. Leo Towle from the University of Chicago is an established epilepsy researcher and neurophysiologist who uses intracranial ECoG measurements to study memory and language processes. Furthermore, each of these mentors has an excellent track record of administrative and leadership experience: Dr. Grabowecky as former assistant Chair of the Psychology Department, Dr. Paller as the Director of the Cognitive Neuroscience program, Dr. Towle as former Chair of Neurology and President of the American Society of Neurophysiologic Monitoring, and Dr. Suzuki as the Director of the Cognitive Division of the Psychology Department. Training from my mentors will be supplemented by attending four technique-based workshops, four academic conferences each year, as well as weekly meetings with each mentor and scholarly meetings at Northwestern University and the University of Chicago to discuss recent research. The overarching goal for this proposal is to advance my understanding of multisensory and speech related processes in order to conduct leading health-related research and to obtain a tenure-track position at a top research university. Supported by a thorough training regiment, this proposed research will provide a thorough understanding of the mechanisms that support multisensory speech perception and will provide clinically relevant understanding of multisensory processes as a compensatory mechanism.