International Conference on Reproduction, Pregnancy, and Rheumatic Disease

 描述（由申请人提供）：由于风湿性疾病的治疗改善了患者的健康状况，患有这些疾病的女性对怀孕越来越感兴趣。然而，潜在的风湿性疾病增加了母亲和婴儿的健康风险。孕妇有疾病发作、器官损伤、先兆子痫和死亡的风险。除了胎儿丢失率高，后代面临早产和胎儿生长受限的长期健康后果的风险。这些风险使得妊娠期风湿性疾病的适当管理至关重要，但如何最好地管理这一点仍不清楚。这次国际会议将汇集世界各地的领导人在这一领域分享 现有数据、临床经验和潜在研究领域。这些交流将有助于制定最终影响患者护理的治疗策略和研究思路。这个为期三天的会议延续了二十年的传统，在风湿性疾病妊娠领域的领先专家之间举行国际两年一次的会议。自2002年以来，该会议一直没有在美国举行，并将为对该领域感兴趣的美国供应商提供参与的机会。会议将有两个总体目标：1。向该领域的研究人员介绍新的研究成果和研究方法; 2.）汇集该领域专家的知识和实践，向更广泛的风湿病学和产科社区传播信息。一个辅助目标是促进网络建设合作研究。 分享知识的第一个目标将通过一系列简短的讲座和抽象的演示来实现。最近完成的两个大型美国-基于研究妊娠风湿病将提出和分歧的调查结果将进行讨论。同时举行的会议将侧重于新的研究方法，以激发新的研究项目，并以临床意义和一致的格式构建研究。将特别注意通过介绍摘要和具有挑战性的案例来鼓励学员参与。 第二个目标是传播会议的结果，将通过手稿来实现。第一个将解决新的FDA妊娠和哺乳期标签规则。这将包括关于如何解释动物，人类和哺乳数据的信息，以及系统性狼疮和类风湿性关节炎妊娠背景风险的评估。本文将指导临床医生选择风湿病治疗方法。第二份手稿将汇编专家在新生儿狼疮先天性心脏传导阻滞（CHB）的筛查，预防和管理方面的实践，因为目前在这一领域的实践存在很大差异。这将通过会前调查问卷完成，然后讨论结果和现有数据，并提出简要建议。一个国家的艺术文件将报告具有挑战性的情况下，他们的管理意见，其他重要的介绍。 这次会议将是互动式的，为建立网络提供充足的时间，并促进专家和学员之间的合作。它将激励美国在这一领域的努力，并促进未来的协调研究工作。

 DESCRIPTION (provided by applicant): As therapies for rheumatic diseases have improved the well-being of patients, women with these diseases are increasingly interested in pregnancy. However, underlying rheumatologic disease increases the health risks for both mother and baby. Pregnant women are at risk for disease flare, organ damage, preeclampsia, and death. Beyond a high rate of fetal loss, offspring are at risk for long-term health consequences from preterm birth and fetal growth restriction. These risks make appropriate management of rheumatologic disease in pregnancy essential, but how best to manage to do this remains unclear. This international conference will bring together worldwide leaders in this field to share existing data, clinical experience, and areas of potential study. These interchanges will help to formulate treatment strategies and research ideas that will ultimately impact patient care. This three day conference continues the two-decade tradition of international biennial meetings among leading experts in the field of pregnancy in rheumatic diseases. This meeting has not taken place in the U.S. since 2002 and will give US providers interested in this area an opportunity to participate. The conference will have two overarching goals: 1.) to update researchers in this field about new study results and research methods; and 2.) to aggregate the knowledge and practices of experts in this field to disseminate information to the wider rheumatology and obstetrics communities. An adjunct goal is to facilitate networking to build collaborative research. The first goal of sharing knowledge will be met through a series of short lectures and abstract presentations. The results of two large recently-completed U.S.-based studies of pregnancy in rheumatologic disease will be presented and the ramifications of the findings will be discussed. A concurrent session will focus on novel approaches to research, to both inspire new research projects and to structure research in clinically meaningful and aligned formats. Special attention will be made to encourage trainee involvement through presentations of abstracts and challenging cases. The second goal of disseminating the findings of the conference will be accomplished through manuscripts. The first will address the new FDA Pregnancy and Lactation Labeling Rule. This will include information about how to interpret animal, human and lactation data, and an assessment of the background risk of pregnancy from systemic lupus and rheumatoid arthritis. This paper will guide clinicians in choosing rheumatologic therapies. The second manuscript will compile the practices of experts in screening, prevention, and management of congenital heart block (CHB) from neonatal lupus, as current practice in this area is widely variable. This will be accomplished through a pre-meeting questionnaire, followed by a discussion of the results and the existing data with summary recommendations. A State of the Art paper will report challenging cases and opinions on their management, other important presentations. This conference will be interactive, provide ample time for networking, and foster collaboration between experts and trainees. It will galvanize the U.S-based efforts in this field and promote future coordinated research efforts.