Regulatable Gene Expression for Prevention of Neuropathy
Regulatable Gene Expression for Prevention of Neuropathy
批准号:
8966656
负责人:
DAVID J. FINK
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-10-01 至 2017-09-30
关键词:
AddressAnimal ModelAnimalsAntineoplastic AgentsBehaviorChemotherapy-induced peripheral neuropathyCisplatinClinicClinicalClinical TreatmentClinical TrialsDevelopmentDiabetes MellitusDiabetic NeuropathiesDoseDose-LimitingDoxycyclineErythropoietinFDA approvedGene ExpressionGene TransferHSV vectorInterleukin-10InterventionIntractable PainKineticsMalignant NeoplasmsModelingMorphologyNerveNerve FibersNeuronsNeuropathyNeurotrophin 3PaclitaxelPainPatientsPeptidesPeripheral Nervous SystemPharmaceutical PreparationsPhase II Clinical TrialsPhysiciansPreventionQuality of lifeRattusRodent ModelSimplexvirusSpinal GangliaTestingTetanus Helper PeptideTimeToxic effectTranslatingVeteransWorkabstractingbasechemotherapyclinical applicationclinically relevantdensitydesigndiabeticdisabilityexpression vectormouse modelneurotrophic factorpain behaviorpreclinical studypreproenkephalinpreventprotective effectpublic health relevanceresponsesciatic nervesymptom managementtransgene expressionvectorvector-induced
中文摘要
描述(由申请人提供):
英文摘要
DESCRIPTION (provided by applicant):
PROJECT SUMMARY/ABSTRACT Chemotherapy-induced peripheral neuropathy (CIPN) is the dose-limiting toxicity for many commonly utilized classes of anti-cancer agents, and there are no currently available FDA-approved interventions to prevent CIPN. In animal models CIPN can be prevented by systemic administration of neurotrophic factors, but translating these findings into a clinical treatment has been limited by off-target effects that preclude systemic administration. Over the past decade we have addressed this issue by gene transfer using vectors created from replication incompetent herpes simplex virus (HSV) to achieve local release of peptides from dorsal root ganglion (DRG) neurons, and our HSV vector expressing preproenkephalin is now in a phase 2 clinical trial for treatment of intractable pain. To safely express neurotrophic factors n the peripheral nervous system for a condition that extends over a prolonged timeframe, it will be essential to be able to regulate transgene expression. Studies proposed in this application are designed to extend our previous work to determine whether regulated expression of either neurotrophin-3 (NT3) and/or interleukin-10 (IL10) from non-replicating HSV vectors can be used to prevent CIPN.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Regulatable Gene Expression for Prevention of Neuropathy
-
批准号:8540668
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2013
-
负责人:DAVID J. FINK
-
依托单位:
Preclinical Development of an NT3-expressing HSV Vector
-
批准号:8100576
-
项目类别:
-
资助金额:$100.18万
-
财政年份:2011
-
负责人:DAVID J. FINK
-
依托单位:
Preclinical Development of an NT3-expressing HSV Vector
-
批准号:8549318
-
项目类别:
-
资助金额:$104.71万
-
财政年份:2011
-
负责人:DAVID J. FINK
-
依托单位:
Preclinical Development of an NT3-expressing HSV Vector
-
批准号:8326048
-
项目类别:
-
资助金额:$105.61万
-
财政年份:2011
-
负责人:DAVID J. FINK
-
依托单位:
HSV GAD for Painful Diabetic Neuropathy
-
批准号:7870164
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2010
-
负责人:DAVID J. FINK
-
依托单位:
HSV GAD for Painful Diabetic Neuropathy
-
批准号:8466768
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2010
-
负责人:DAVID J. FINK
-
依托单位:
PAINFUL DIABETIC NEUROPATHY
-
批准号:7083037
-
项目类别:
-
资助金额:$36.16万
-
财政年份:2006
-
负责人:DAVID J. FINK
-
依托单位:
Gene Therapy for Pain
-
批准号:6665163
-
项目类别:
-
资助金额:$43.11万
-
财政年份:2002
-
负责人:DAVID J. FINK
-
依托单位:
Gene Therapy for Pain
-
批准号:6546992
-
项目类别:
-
资助金额:$41.99万
-
财政年份:2002
-
负责人:DAVID J. FINK
-
依托单位:
Gene Therapy for Pain
-
批准号:6951234
-
项目类别:
-
资助金额:$45.63万
-
财政年份:2002
-
负责人:DAVID J. FINK
-
依托单位:
Gene Therapy for Pain
-
批准号:6793538
-
项目类别:
-
资助金额:$44.3万
-
财政年份:2002
-
负责人:DAVID J. FINK
-
依托单位:
CORE--VECTOR DESIGN AND PRODUCTION
-
批准号:6494881
-
项目类别:
-
资助金额:$38.25万
-
财政年份:2001
-
负责人:DAVID J. FINK
-
依托单位:
CORE--VECTOR DESIGN AND PRODUCTION
-
批准号:6496812
-
项目类别:
-
资助金额:$17.32万
-
财政年份:2001
-
负责人:DAVID J. FINK
-
依托单位:
CORE--VECTOR DESIGN AND PRODUCTION
-
批准号:6356596
-
项目类别:
-
资助金额:$24.9万
-
财政年份:2000
-
负责人:DAVID J. FINK
-
依托单位:
CORE--VECTOR DESIGN AND PRODUCTION
-
批准号:6358106
-
项目类别:
-
资助金额:$38.25万
-
财政年份:2000
-
负责人:DAVID J. FINK
-
依托单位:
CORE--VECTOR DESIGN AND PRODUCTION
-
批准号:6296992
-
项目类别:
-
资助金额:$23.94万
-
财政年份:1999
-
负责人:DAVID J. FINK
-
依托单位:
GENE TRANSFER FOR PREVENTION OF DIABETIC NEUROPATHY
-
批准号:6394158
-
项目类别:
-
资助金额:$19.46万
-
财政年份:1999
-
负责人:DAVID J. FINK
-
依托单位:
Gene Transfer for Prevention of Diabetic Neuropathy
-
批准号:8049066
-
项目类别:
-
资助金额:$32.59万
-
财政年份:1999
-
负责人:DAVID J. FINK
-
依托单位:
Gene Transfer for Prevention of Diabetic Neuropathy
-
批准号:8258766
-
项目类别:
-
资助金额:$32.59万
-
财政年份:1999
-
负责人:DAVID J. FINK
-
依托单位:
Gene Transfer for Prevention of Diabetic Neuropathy
-
批准号:7618659
-
项目类别:
-
资助金额:$33.25万
-
财政年份:1999
-
负责人:DAVID J. FINK
-
依托单位:
海外基金