Center for Evaluation and Coordination of Training and Research in TRS

修改项目摘要/摘要部分 描述（由申请人提供）：在健康实施科学的从实验室到床边的模式中，烟草监管科学（TRS）面临着类似的挑战，即首先将当前的基础工作转化为正式的监管科学学科，并最终（但很快）转化为政策和监管实施，最终导致烟草相关疾病和死亡的减少。为了应对这一挑战，美国国立卫生研究院和美国食品药品监督管理局需要一种机制来组织、监测、评估、应对和规划当前和未来的研究，既作为单独的项目，也作为一个协调的、有目的的组合，遵循研究的发展路径，从而采取基于科学的烟草监管行动。CECTR将是这一进程的核心。Westat很高兴与美国遗产基金会（Schroeder-Legacy）的施罗德烟草研究与政策研究所（Schroeder Institute for Tobacco Research and Policy Studies）合作，创建CECTR，其基本前提是，完成这一使命需要将新兴TRS领域的深厚科学技术专长和知识与管理大型协调中心和其他复杂支持项目的卓越运营能力相结合。在共同PD/PI Jeanne Rosenthal（MPH（Westat））和大卫艾布拉姆斯博士（Schroeder-Legacy）的领导下，并由一批资深烟草科学家和经验丰富的评估人员、培训开发人员、方法学家、流行病学家、分析师和统计学家组成，我们的方法在高度支持和高效的基础设施内提供科学领导和研究技术专长。Westat团队将专注于实现以下具体目标：（1）通过促进合作和沟通来加速知识共享和创新;（2）及时提供TRS概念模型、共同措施和其他政策相关研究工具;（3）通过协调CTP的跨学科培训，提高研究界开展更快速、更有效的TRS的能力-资助科学家并促进数据共享、分析和综合;以及（4）提高TRS的质量和创新性，扩大研究能力，通过严格的评估流程产生为政策和实践提供信息的成果。

Modified Project Summary/Abstract Section DESCRIPTION (provided by applicant): In the mold of the bench-to-bedside paradigm for health implementation science, tobacco regulatory science (TRS) faces a similar challenge of translating the current foundational work first into a formal regulatory science discipline and eventually (but quickly) to policy and regulatory implementation that leads ultimately to the reduction of tobacco-related disease and death. To address this challenge, the National Institutes of Health and the Food and Drug Administration need a mechanism to organize, monitor, assess, react to, and plan current and future research, both as individual projects and as a harmonized, purposive portfolio that follows a developing path for the research, leading to science-based tobacco regulatory actions. The CECTR will be central to this process. Westat is pleased to join with the Schroeder Institute for Tobacco Research and Policy Studies of the American Legacy Foundation (Schroeder-Legacy) to create a CECTR based on the fundamental premise that fulfilling this mission requires an integration of deep scientific and technical expertise and knowledge in the nascent field of TRS with outstanding operational capabilities in managing large coordinating centers and other complex support projects. Led by co-PD/PIs Jeanne Rosenthal, MPH (Westat), and David Abrams, PhD (Schroeder-Legacy), and staffed by a cadre of senior tobacco scientists and highly experienced evaluators, training developers, methodologists, epidemiologists, analysts, and statisticians, our approach provides scientific leadership and research technical expertise within a highly supportive and efficient infrastructure. The Westat team will focus on achieving the following specific aims: (1) accelerate knowledge sharing and innovation by facilitating collaboration and communication; (2) increase the timely availability of TRS conceptual models, common measures and other tools for policy relevant research; (3) enhance the capacity of the research community to conduct more rapid and impactful TRS by coordinating cross-disciplinary training of CTP-funded scientists and facilitating data sharing, analysis, and synthesis; and (4) enhance the quality and innovativeness of TRS and expand the research capacity to produce results that inform policy and practice through a rigorous evaluation process.