Effects of Vitamin D and Omega-3 on Cerebrovascular Disease

维生素 D 和 Omega-3 对脑血管疾病的影响

• 批准号: 9107541
• 负责人: PAMELA M. RIST
• 金额: $ 14.57万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9107541
• 关键词: 25-hydroxyvitamin D; Admission activity; Animals; Applications Grants; Aspirin; Award; Biological Markers; Brain; Brain Injuries; Cardiovascular Diseases; Caring; Case-Control Studies; Cerebral Infarction; Cerebrovascular Disorders; Cholecalciferol; Chronic; Clinical; Clinical Trials; Contralateral; Data; Data Analyses; Data Set; Databases; Development; Development Plans; Docosahexaenoic Acids; Dose; Double-blind trial; Eating; Eicosapentaenoic Acid; Epidemiology; Event; Fishes; Funding; Future; Goals; Grant; Hospitals; Human; Immune response; Impaired cognition; Incidence; Individual; Ischemic Stroke; K-Series Research Career Programs; Learning; MRI Scans; Magnetic Resonance Imaging; Malignant Neoplasms; Marines; Measures; Mediating; Mediation; Medical; Mental Depression; Mentored Research Scientist Development Award; Mentors; Mentorship; Meta-Analysis; Morbidity - disease rate; Neuronal Plasticity; Observational Study; Omega-3 Fatty Acids; Outcome; Parents; Participant; Pathway interactions; Patients; Play; Population; Primary Cancer Prevention; Primary Prevention; Randomized; Randomized Clinical Trials; Research; Research Personnel; Risk; Risk Factors; Role; Series; Serum; Severities; Source; Stroke; Supplementation; Techniques; Testing; Training; United States National Institutes of Health; Vitamin D; Vitamin D supplementation; Vitamin E; White Matter Hyperintensity; Woman; Women' s Health; Work; base; bone; burden of illness; cardiovascular disorder epidemiology; cardiovascular disorder risk; career; career development; cerebral microbleeds; cerebrovascular; cost effective; design; disability; experience; falls; fatty acid supplementation; follow-up; functional outcomes; improved; interest; mortality; post stroke; prospective; public health relevance; randomized trial; reduced muscle strength; skills; stroke intervention

 DESCRIPTION (provided by applicant): My long-term goal is to become an independent researcher in cardiovascular epidemiology with a focus on the morbidity burden associated with cerebrovascular diseases, particularly stroke. I will use this Mentored Career Development award (K01) to fulfill a series of training objectives which build upon my prior skills, but also expand my expertise in ways which are essential to accomplishing my long-term goal. These include: learning to measure and analyze longitudinal stroke outcomes data; developing skills to assess, characterize, and measure white matter hyperintensity volume (WMHV) and cerebral microbleeds (CMBs) from magnetic resonance imaging (MRI) scans; learning about the design, conduct, and analysis of randomized clinical trials; and acquiring skills in mediation analysis techniques. To achieve my training objectives, I have assembled a comprehensive and complementary mentorship team which has worked together and with me for many years. My training objectives will also allow me to develop the skills needed to establish new datasets within ongoing studies during this award period. These subcohorts are necessary to achieve the research goals of the K01 and will provide preliminary data for future grant applications for independent research funding. I will apply my training to several important research questions during this K01 award. Recently, there has been growing interest in the role that vitamin D as well as omega-3 fatty acids play in the development of cardiovascular disease events. Given the high morbidity burden of stroke, determining the effect of these supplements on stroke outcomes is very important. The NIH sponsored VITamin D and OmegA-3 TriaL (VITAL) is an ongoing randomized, double blind trial testing vitamin D3 and omega-3 fatty acid supplementation in the primary prevention of cancer and cardiovascular disease. I will leverage this ongoing trial and collect additional data on stroke outcomes that would not otherwise be collected by the parent study. In addition, there is growing interest in discovering risk factors fr overall subclinical cerebrovascular disease burden in the brain as measured by WMHV and CMBs. Because WMHV and CMBs are associated with stroke outcomes, understanding risk factors associated with WMHV and CMBs in ischemic stroke patients may identify strategies to reduce the morbidity burden of stroke. I will collect MRI scans performed as part of routine medical care in participants with an ischemic stroke to create a database of WMHV and CMBs in VITAL and the Women's Healthy Study (WHS), a completed trial of the effects of low dose aspirin and vitamin E in the primary prevention of cardiovascular disease and cancer with ongoing observational follow-up. By using data from both VITAL and WHS, I will have the unique opportunity to study how a wide variety of cardiovascular disease risk factors impact WMHV and CMBs in stroke patients. The training, mentorship, research experience, and opportunity to establish new subcohorts provided by this K01 award will allow me to achieve my long-term career goal of becoming an independent research in cardiovascular disease epidemiology.

 描述（由申请人提供）：我的长期目标是成为心血管流行病学的独立研究人员，重点关注与脑血管疾病，特别是中风相关的发病率负担。我将使用这个指导职业发展奖（K 01）来实现一系列的培训目标，这些目标建立在我以前的技能基础上，同时也以实现我的长期目标所必需的方式扩展我的专业知识。其中包括：学习测量和分析纵向卒中结局数据;发展评估、表征和测量磁共振成像（MRI）扫描的白色高信号体积（WMHV）和脑微出血（CMB）的技能;学习随机临床试验的设计、实施和分析;获得中介分析技术的技能。为了实现我的培训目标，我组建了一个全面而互补的导师团队，他们与我一起工作了多年。我的培训目标也将使我能够在此奖项期间发展在正在进行的研究中建立新数据集所需的技能。这些子队列对于实现K 01的研究目标是必要的，并将为未来的独立研究资金拨款申请提供初步数据。 在K 01获奖期间，我将把我的培训应用于几个重要的研究问题。最近，人们越来越关注维生素D和ω-3脂肪酸在心血管疾病事件发展中的作用。鉴于中风的高发病率负担，确定这些补充剂对中风结局的影响非常重要。NIH赞助的Vitamin D和OmegA-3 TriaL（VITAL）是一项正在进行的随机双盲试验，测试维生素D3和omega-3脂肪酸补充剂在癌症和心血管疾病的一级预防中的作用。我将利用这项正在进行的试验，并收集有关卒中结局的其他数据，这些数据将不会被母研究收集。此外，通过WMHV和CMB测量发现脑中亚临床脑血管疾病总体负荷的风险因素也越来越受到关注。由于WMHV和CMB与卒中结局相关，因此了解缺血性卒中患者中与WMHV和CMB相关的风险因素可能有助于确定降低卒中发病率负担的策略。我将收集作为缺血性卒中参与者常规医疗护理的一部分进行的MRI扫描，以创建VITAL和妇女健康研究（WHS）中的WMHV和CMB数据库，这是一项关于低剂量阿司匹林和维生素E在心血管疾病和癌症一级预防中的作用的完整试验，并进行观察性随访。通过使用VITAL和WHS的数据，我将有独特的机会研究各种心血管疾病风险因素如何影响中风患者的WMHV和CMB。K 01奖提供的培训，指导，研究经验和建立新的子队列的机会将使我能够实现成为心血管疾病流行病学独立研究的长期职业目标。