2016 Biology of Acute Respiratory Infection Gordon Research Conference & Gordon Research Seminar

 描述(由申请人提供)： 项目摘要急性呼吸道感染是全世界发病率和死亡率的主要原因。处于危险中的人口结构的变化，再加上新的和具有抗药性的微生物病原体的出现，表明疾病的负担几乎肯定会恶化。2016年戈登急性呼吸道感染生物学研究会议(GRC)将重点介绍肺部感染的新范式，包括对 病原体识别和细胞参与；抗微生物效应机制；呼吸道感染中肺损伤和修复的调节；肺免疫记忆的发展；新出现的呼吸道病原体；肺微生物群在健康和疾病中的作用；微生物发病机制；宿主反应的遗传和环境调节；以及急性呼吸道感染患者宿主反应的预防和描述策略。已经召集了一个国际专家组，对这些快速发展的领域提供最新的概述。急性呼吸道感染生物学GRC和相关的戈登研究研讨会为基础生物学家、转化型科学家和临床研究人员组成的多学科小组之间的创造性和动态交流提供了一个理想的场所。对所涉基本机制的基本了解将有助于开发诊断、预防和治疗严重呼吸道感染的创新方法。

 DESCRIPTION (provided by applicant): Project Summary Acute respiratory tract infections account for substantial morbidity and mortality worldwide. The changing demographics of the population at risk, combined with the emergence of new and resistant microbial pathogens suggest that the burden of disease will almost certainly worsen. The 2016 Gordon Research Conference (GRC) on Biology of Acute Respiratory Infection will highlight new paradigms in lung infection, including novel insights into pathogen recognition and cellular participants involved, antimicrobial effector mechanisms, regulation of lung injury and repair in respiratory infection, the development of lung immune memory, emerging respiratory pathogens, the lung microbiome in health and disease, mechanisms of microbial pathogenesis, genetic and environmental regulation of the host response, and strategies for the prevention and profiling of the host response in patients with acute respiratory tract infections. An international group of experts have been assembled to provide cutting-edge overviews of these rapidly evolving fields. The GRC on Biology of Acute Respiratory Infection and associated Gordon Research Seminar provide an ideal venue for the creative and dynamic exchange between a multidisciplinary group of basic biologists, translational scientists, and clinical investigators. A fundamental understanding of basic mechanisms involved will foster the development of innovative approaches to the diagnosis, prevention and treatment of serious infections of the respiratory tract.