2016 Biology of Acute Respiratory Infection Gordon Research Conference & Gordon Research Seminar

 描述（由申请人提供）： 急性呼吸道感染在全世界范围内占发病率和死亡率的很大一部分。高危人群的人口结构不断变化，加上新的耐药微生物病原体的出现，表明疾病负担几乎肯定会恶化。2016年戈登急性呼吸道感染生物学研究会议（GRC）将突出肺部感染的新范式，包括对以下方面的新见解： 病原体识别和涉及的细胞参与者，抗微生物效应器机制，呼吸道感染中肺损伤和修复的调节，肺免疫记忆的发展，新出现的呼吸道病原体，健康和疾病中的肺微生物组，微生物发病机制，宿主反应的遗传和环境调节，以及急性呼吸道感染患者中宿主反应的预防和分析策略。一个国际专家组已经成立，为这些迅速发展的领域提供最前沿的概述。急性呼吸道感染生物学的GRC和相关的戈登研究研讨会为基础生物学家，翻译科学家和临床研究人员的多学科小组之间的创造性和动态交流提供了理想的场所。对所涉及的基本机制的基本理解将促进发展诊断、预防和治疗严重呼吸道感染的创新方法。

 DESCRIPTION (provided by applicant): Project Summary Acute respiratory tract infections account for substantial morbidity and mortality worldwide. The changing demographics of the population at risk, combined with the emergence of new and resistant microbial pathogens suggest that the burden of disease will almost certainly worsen. The 2016 Gordon Research Conference (GRC) on Biology of Acute Respiratory Infection will highlight new paradigms in lung infection, including novel insights into pathogen recognition and cellular participants involved, antimicrobial effector mechanisms, regulation of lung injury and repair in respiratory infection, the development of lung immune memory, emerging respiratory pathogens, the lung microbiome in health and disease, mechanisms of microbial pathogenesis, genetic and environmental regulation of the host response, and strategies for the prevention and profiling of the host response in patients with acute respiratory tract infections. An international group of experts have been assembled to provide cutting-edge overviews of these rapidly evolving fields. The GRC on Biology of Acute Respiratory Infection and associated Gordon Research Seminar provide an ideal venue for the creative and dynamic exchange between a multidisciplinary group of basic biologists, translational scientists, and clinical investigators. A fundamental understanding of basic mechanisms involved will foster the development of innovative approaches to the diagnosis, prevention and treatment of serious infections of the respiratory tract.