Optimization of Cancer Therapy guided by oxygen, pH, thiol and other parametric images

电子顺磁共振(EPR)氧气成像(EPROI)已被证明提供了定量 动物肿瘤的局部化pO2图像，包括同基因小鼠、大鼠和兔的几个肿瘤。这个 父母赠款在统计上显著提高了50%的肿瘤控制剂量 添加由小于10托(HF10)的EPROI体素分数提供的信息。具体目标 对于当前授权周期：1)确定来自 EPROI和匹莫硝唑滞留，诱导低氧蛋白和单次活检低氧分数。2) 氧显像后TCD50对小鼠肿瘤的治疗及预测效果的测定 HF10和其他EPROI肿瘤统计数据以及3)使用来自EPROI的HF10给涂料区域添加 用调强放射治疗判断EPROI对小鼠肿瘤治疗的影响。这项工作将验证 定量氧成像在优化辐射传输和刺激氧发展中的作用 用于治疗人类肿瘤的成像技术。研究专家职位的经费将加强 通过引入共形射束辐射使母赠款获得成功所需的技术 PH和氧化还原状态引导调强放射治疗的方案和开发技术 小鼠肿瘤。这种支持将为在赠款周期之间获得资金提供充足的时间。

Electron Paramagnetic Resonance (EPR) Oxygen Images (EPROI) have been shown to provide quantitative localized pO2 images of animal tumors including several in syngeneic mice, and in rats, and rabbits. The parent grant has demonstrated statistically significant sharpening of the 50% tumor control dose with the addition of the information provided by the fraction of EPROI voxels less than 10 torr (HF10). Specific aims for the current grant cycle: 1) Determining the relation between the localized oxygen information from the EPROI and pimonidazole retention, induction of hypoxia proteins and single biopsy hypoxic fraction. 2) Treatment of murine tumors to TCD50 after oxygen images and determining the predictive effectiveness of the HF10 and other EPROI tumor statistics and 3) Using the HF10 from EPROI to dose paint regions of hypoxia with IMRT to determine the impact of the EPROI on cure of mouse tumors. This work will validate quantitative oxygen imaging in optimizing radiation delivery and stimulate the development of oxygen imaging for treatment of human tumors. The funding of the Research Specialist position will enhance the technology required for the success of the parent grant through introduction of conformal beam radiation protocol and develop technology for pH and redox status guided intensity modulated radiation therapy in mouse tumors. Such support will provide sufficient time to secure funding between grant cycles.