Development of a Behavioral Economics Guided Just-In-Time Adaptive Intervention to Reduce Heavy Drinking and Loss-of-Control Eating in Female Young Adult Survivors of Sexual or Dating Violence

项目摘要/摘要 拟议的导师研究科学家发展奖的长期目标是启动Dr。 Jacques-Tiura作为独立的社会健康行为变化研究人员的研究计划，专注于 关于年轻女性的上瘾行为。这一目标将通过为期5年的平行培训和 研究计划。培训目标包括培养(1)T1翻译的理论和实践方面的专业知识 干预发展与适应；(2)行为经济学理论及其在成瘾性研究中的应用 行为，(3)移动健康提供(MHealth)干预措施的发展和完善，以及(4) 发展、改进和使用分析数据的统计方法，以便为适应性干预和 适时适应性干预(JITAI)。将通过全面培训来实现培训目标 计划包括(1)与导师Sylvie Naar博士、Mark Greenwald博士、Steven博士进行持续的一对一会议 Ondersma和Inbal Nahum-Shani，(2)讲习班和暑期研习班，(3)会议，(4)研讨会和 (5)负责任地开展研究的课程。通过培训计划获得的技能将用于 通过互补的三阶段研究计划采取行动。第一阶段，将在第一年和第二年完成， 涉及干预前发展的基本行为科学。为了解决目标1，我们将在线收集 调查数据来自300名18-25岁的年轻女性，以检验与常见行为经济因素有关的 性暴力和/或约会暴力幸存者中的大量间歇性饮酒和失控进食 (SVDV)，如酒精和食品的相对强化价值、酒精和食品的延迟折扣、成本和 酒精和低碳水化合物摄入的后果，以及非酒精和与食物相关的活动的强化。 结果将指导干预和开发以及第二阶段(T1翻译)的Beta测试。第二阶段，待定 在2-3年内完成，包括开发和Beta测试为期12周的在线行为经济指导 吉泰与12名SVDV幸存者一起减少HED和LOC的进食行为，以解决目标2。阶段3，将 在第4年和第5年完成，重点是概念验证，涉及可行性和初步效果 在第二阶段对干预措施进行测试。目标3a涉及参与者的可行性和精细化 方法和干预内容，目标3b涉及通过在- 受试者与36名SVDV幸存者进行多基线先导研究。拟议的研究将为以下项目提供试点数据 Jacques-Tiura博士向NIAAA提交的第一份R01提案，将于第五年提交。 Ondersma和Nahum-Shani将分享他们在(1)卫生干预的T1翻译方面的专业知识，(2) 行为经济学，(3)移动健康，(4)吉泰研究设计和统计分析。韦恩州立大学 大学提供了合适的资源和富有成效的环境，为成瘾者的职业发展提供了成熟的条件 行为。这项提议与NIH研究职业发展计划的总体目标是一致的 确保培训多样化的科学家，以满足美国的行为和生物医学需求。

PROJECT SUMMARY/ABSTRACT The long-term objective of the proposed Mentored Research Scientist Development Award is to launch Dr. Jacques-Tiura’s program of research as an independent social health behavioral change researcher focusing on young women’s addictive behaviors. This goal will be achieved through a 5-year parallel training and research plan. Training objectives involve building expertise in (1) the theory and practice of T1 translation intervention development and adaption, (2) behavioral economic theory and its application to addictive behaviors, (3) the development and refinement of mobile health-delivered (mHealth) interventions, and (4) the development, refinement, and use of statistical methods of analyzing data to inform adaptive interventions and just-in-time adaptive interventions (JITAIs). Training objectives will be met through a comprehensive training plan involving (1) ongoing one-on-one meetings with mentors Drs. Sylvie Naar, Mark Greenwald, Steven Ondersma, and Inbal Nahum-Shani, (2) workshops and summer institutes, (3) conferences, (4) seminars, and (5) coursework for the responsible conduct of research. Skills gained through the training plan will be put into action through the complementary three-phase research plan. Phase 1, to be completed in Years 1 and 2, involves basic behavioral science of pre-intervention development. To address Aim 1, we will collect online survey data from 300 young women age 18-25 to examine common behavioral economic factors related to heavy episodic drinking (HED) and loss-of-control (LOC) eating among sexual and/or dating violence survivors (SVDV), such as relative reinforcing value of alcohol and food, delay discounting of alcohol and food, costs and consequences of alcohol and LOC eating, and reinforcement from non-alcohol and food-related activities. Results will guide intervention and development and beta testing in Phase 2 (T1 translation). Phase 2, to be completed in Years 2-3, involves developing and beta testing the 12-week online behavioral economic-guided JITAI to reduce HED and LOC eating behaviors with 12 SVDV survivors, to address Aim 2. Phase 3, to be completed in Years 4 and 5, focuses on proof of concept and involves feasibility and preliminary efficacy testing of the intervention developing in Phase 2. Aim 3a concerns feasibility and refinement of participant methods and intervention content, and Aim 3b concerns testing invention efficacy by conducting a within- subjects multiple baseline pilot study with 36 SVDV survivors. The proposed studies will provide pilot data for Dr. Jacques-Tiura’s first R01 proposal to NIAAA, to be submitted in Year 5. Mentors Drs. Naar, Greenwald, Ondersma, and Nahum-Shani will share their expertise in (1) T1 translation of health intervention, (2) behavioral economics, (3) mHealth, and (4) JITAI research design and statistical analysis. Wayne State University offers suitable resources and a fruitful environment ripe for growing a career in the addictive behaviors. This proposal is aligned with the NIH Research Career Development program’s overall goal of ensuring the training of a diverse pool of scientists to address the USA’s behavioral and biomedical needs.