The Midwest Center for Structural Genomics - Community Resource

中西部结构基因组学中心 - 社区资源

• 批准号: 9115648
• 负责人: ANDRZEJ JOACHIMIAK
• 金额: $ 91.6万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9115648
• 关键词: Antibiotic Resistance; Biochemical; Biochemical Process; Bioinformatics; Biology; Collaborations; Communities; Crystallization; Data; Data Collection; Databases; Disease; Educational Activities; Equipment; Generations; Genomic DNA; Health; Human; Individual; Institution; Laboratories; Midwestern United States; Molecular; Photons; Production; Proteins; Proteomics; Research; Research Personnel; Resources; Robotics; Scientist; Site; Software Tools; Source; Synchrotrons; Systems Biology; Technology; Training; Visit; X-Ray Crystallography; biophysical properties; combat; cost effective; data structure; expression cloning; expression vector; gene cloning; instrumentation; microbial; novel therapeutics; outreach; pathogen; programs; protein expression; protein purification; structural genomics; technology training

 DESCRIPTION (provided by applicant): The primary objective of the Midwest Center for Structural Genomics (MCSG) is to operate the high-throughput protein characterization pipeline as a resource for Biology Community. The platform is well established, highly integrated and cost effective. Is comprised of the following components: bioinformatics, gene cloning, protein expression, protein purification and characterization, crystallization as well as data collection and structure determination using X-ray crystallography at 3rd generation synchrotron. As a part of its mandate, the MCSG will apply its resources for targets nominated by the individual investigators and will serve as a user facility for the U.S. academic and research institutions. The MCSG site has fully functional instrumentation and expertise in place for the task. The MCSG will actively interact with other scientists, conduct technology training and will make all results produced in the course of this program readily available to the scientific community. The MCSG is located in the Advanced Protein Characterization Facility (APCF) at Argonne National Laboratory (ANL) that is directly attached to the Advanced Photon Source (APS) at sector 19. The APCF is a state-of-the-art scientific collaborative facility that provides new, specialized laboratory space devoted to molecular, structural and systems biology.

 描述（由申请人提供）：中西部结构基因组学中心 (MCSG) 的主要目标是运营高通量蛋白质表征管道，作为生物学界的资源。该平台完善、高度集成且具有成本效益。由以下部分组成：生物信息学、基因克隆、蛋白质表达、蛋白质纯化和表征、结晶以及在第三代同步加速器上使用 X 射线晶体学进行数据收集和结构测定。作为其职责的一部分，MCSG 将把其资源用于个别调查人员提名的目标，并将作为美国学术和研究机构的用户设施。 MCSG 站点拥有完成该任务所需的功能齐全的仪器和专业知识。 MCSG 将积极与其他科学家互动，开展技术培训，并将将该计划过程中产生的所有成果随时提供给科学界。 MCSG 位于阿贡国家实验室 (ANL) 的高级蛋白质表征设施 (APCF)，该设施直接连接到第 19 区的高级光子源 (APS)。APCF 是一个最先进的科学协作设施，提供专门用于分子、结构和系统生物学的新型专业实验室空间。