Frontoparietal Network Integrity and Risk for Psychosis

额顶网络完整性和精神病风险

基本信息

  • 批准号:
    9085375
  • 负责人:
  • 金额:
    $ 18.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-09-01 至 2019-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr. Justin Baker, a psychiatrist and neuroscientist at McLean Hospital and the Harvard Medical School. Dr. Baker is establishing himself as a young investigator in patient- oriented clinical research of schizophrenia and bipolar disorder. This K23 award will provide Dr. Baker with the support necessary to accomplish the following goals: (1) to become expert at patient-oriented clinical research in psychotic disorders; (2) to conduct investigations of neurobiological correlates in patients in early stages of psychotic illness; (3) to implement advanced genetic methods in clinical studies; and (4) to develop an independent clinical research career. To achieve these goals, Dr. Baker has assembled a mentoring team comprised of two primary mentors, Dr. Jordan Smoller, Director of Psychiatric Genetics at Massachusetts General Hospital (MGH), who conducts genetic investigations in schizophrenia and bipolar disorder, and Dr. Dost Ongur, Chief of the McLean Hospital Psychotic Disorders Division who leads a neuroimaging laboratory studying the biology of psychotic illness. Consultants include Dr. Randy Buckner, Director of Psychiatric Neuroimaging at MGH, a neuroscientist who contributes advanced neuroimaging expertise, Larry Seidman, a psychologist with expertise in the early phases of schizophrenia and bipolar disorder, and Dr. Ben Neale, an expert in statistics and statistical genetics, particularly in the field of psychiatric genetics. Psychotic disorders, including schizophrenia (SZ and bipolar disorder with psychosis (BPP) are heritable conditions, and yet little is known about changes to brain structure and function that may arise from genetic variation and in turn confer clinical risk. Dr. Baker's research will focus on the neural system changes that accompany elevated genetic risk for SZ and BPP in a psychiatrically healthy young adult population (Aim 1) and the neural system changes that accompany early stages of SZ and BPP (Aim 2). In Aim 1, Dr. Baker will establish the effects of polygenic risk factors for SZ and BPP, obtained from the Psychiatric Genetics Consortium, on brain structure and function, by leveraging a large existing imaging-genetics sample (>1800) from psychiatrically healthy individuals. In addition, he will create a novel polygenic risk score based on variation in brain function in healthy volunteers and test whether this score informs clinical outcomes in a cross-diagnostic patient sample. In Aim 2, Dr. Baker will analyze two data sets of brain MRI from early stages of psychosis: one from an existing sample of structural and functional MRI scans obtained from patients prodromal for psychosis from the North American Prodrome Longitudinal Study; for the second, Dr. Baker will conduct a cross-sectional pilot study to generate preliminary data on the effects of newly diagnosed psychosis on brain structure and function, leveraging the clinical services of the McLean Psychotic Disorders Division. This research will form the basis for a study of risk prediction modeling in high risk and newly diagnosed schizophrenia and bipolar disorder, to be proposed in an R01 grant application before the end of the K award.
描述(由申请人提供):这是一份K23奖的申请,申请人是姆克林医院和哈佛医学院的精神病学家和神经科学家贾斯汀·贝克博士。贝克博士正在建立自己作为一个年轻的研究者在病人为导向的临床研究, 精神分裂症和躁郁症。该K23奖将为Baker博士提供必要的支持,以实现以下目标:(1)成为精神病患者临床研究的专家;(2)在精神病患者的早期阶段进行神经生物学相关性的调查;(3)在临床研究中实施先进的遗传方法;(4)发展独立的临床研究生涯。为了实现这些目标,Baker博士组建了一个由两名主要导师组成的指导团队,一位是马萨诸塞州总医院(MGH)精神病遗传学主任Jordan Smoller博士,他对精神分裂症和双相情感障碍进行遗传学研究,另一位是姆克林医院精神障碍科主任Dost Ongur博士,他领导一个研究精神病生物学的神经影像实验室。顾问包括MGH精神病学神经影像学主任Randy Buckner博士,他是一位神经科学家,贡献了先进的神经影像学专业知识,Larry Seidman是一位在精神分裂症和双相情感障碍早期阶段具有专业知识的心理学家,Ben Neale博士是统计学和统计遗传学专家,特别是在精神病学遗传学领域。精神障碍,包括精神分裂症(SZ)和双相情感障碍伴精神病(BPP)是遗传性疾病,但对遗传变异可能引起的大脑结构和功能变化知之甚少,这些变化反过来又会带来临床风险。贝克博士的研究将集中在神经系统的变化,伴随SZ和BPP的遗传风险升高,在精神健康的年轻成人人群(目标1)和神经系统的变化,伴随SZ和BPP的早期阶段(目标2)。在目标1中,Baker博士将通过利用来自精神病学健康个体的大量现有成像遗传学样本(>1800),确定从精神病学遗传学联盟获得的SZ和BPP的多基因风险因素对大脑结构和功能的影响。此外,他还将根据健康志愿者脑功能的变化创建一种新的多基因风险评分,并测试该评分是否能反映交叉诊断患者样本的临床结果。在目标2中,Baker博士将分析两组来自精神病早期阶段的脑MRI数据集:一组来自北美前驱症状纵向研究中精神病前驱症状患者的结构和功能MRI扫描的现有样本;第二,贝克博士将进行一项横断面试点研究,以产生关于新诊断的精神病对大脑结构和功能影响的初步数据,充分利用姆克林精神疾病科的临床服务这项研究将为高风险和新诊断的精神分裂症和双相情感障碍的风险预测建模研究奠定基础,该研究将在K奖结束前在R 01资助申请中提出。

项目成果

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JUSTIN T BAKER其他文献

JUSTIN T BAKER的其他文献

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{{ truncateString('JUSTIN T BAKER', 18)}}的其他基金

SCH: INT: Collaborative Research: Context-Adaptive Multimodal Informatics for Psychiatric Discharge Planning
SCH:INT:合作研究:用于精神病出院计划的上下文自适应多模态信息学
  • 批准号:
    10573225
  • 财政年份:
    2021
  • 资助金额:
    $ 18.23万
  • 项目类别:
SCH: INT: Collaborative Research: Context-Adaptive Multimodal Informatics for Psychiatric Discharge Planning
SCH:INT:合作研究:用于精神病出院计划的上下文自适应多模态信息学
  • 批准号:
    10392429
  • 财政年份:
    2021
  • 资助金额:
    $ 18.23万
  • 项目类别:
Robust Predictors of Mania and Psychosis
躁狂症和精神病的稳健预测因子
  • 批准号:
    10164863
  • 财政年份:
    2018
  • 资助金额:
    $ 18.23万
  • 项目类别:
Robust Predictors of Mania and Psychosis
躁狂症和精神病的稳健预测因子
  • 批准号:
    9755521
  • 财政年份:
    2018
  • 资助金额:
    $ 18.23万
  • 项目类别:
Robust Predictors of Mania and Psychosis
躁狂症和精神病的稳健预测因子
  • 批准号:
    9920544
  • 财政年份:
    2018
  • 资助金额:
    $ 18.23万
  • 项目类别:
Robust Predictors of Mania and Psychosis
躁狂症和精神病的稳健预测因子
  • 批准号:
    10571298
  • 财政年份:
    2018
  • 资助金额:
    $ 18.23万
  • 项目类别:
Modulation of the OCD neural network by conventional treatment
通过常规治疗调节强迫症神经网络
  • 批准号:
    10594013
  • 财政年份:
    2015
  • 资助金额:
    $ 18.23万
  • 项目类别:
Modulation of the OCD neural network by conventional treatment
通过常规治疗调节强迫症神经网络
  • 批准号:
    10411710
  • 财政年份:
    2015
  • 资助金额:
    $ 18.23万
  • 项目类别:
Frontoparietal Network Integrity and Risk for Psychosis
额顶网络完整性和精神病风险
  • 批准号:
    9312877
  • 财政年份:
    2014
  • 资助金额:
    $ 18.23万
  • 项目类别:
Frontoparietal Network Integrity and Risk for Psychosis
额顶网络完整性和精神病风险
  • 批准号:
    8755695
  • 财政年份:
    2014
  • 资助金额:
    $ 18.23万
  • 项目类别:

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