Vascular Moderators of the Impact of Alzheimer's Pathology in the Young-Old

项目-2摘要/摘要： 阿尔茨海默病(AD)的流行与存在密切相关 对于心血管疾病(CAVD)来说，了解AD病理和CAVD之间的关系至关重要 很重要。在本计划项目(PPG3)的竞争性续订中，我们将探索我们的发现 在一个非常年长的队列中，与CAVD和Aβ病理相关的疾病将适用于更多样化的队列。最重要的是 PPG3项目2的目标是进一步了解AD病理与中年的关系 CAVD及这些因素对一组青年老年人认知功能障碍的影响。为了实现这些目标， 我们将利用现有队列中的一组非痴呆参与者，这些参与者来自正在进行的基于社区的 心脏策略专注于风险评估(心脏评分)研究，这是一项始于 2003年，有2000名参与者(43%是非洲裔美国人)参加了研究，年龄在45-75岁之间 并收集了丰富的纵向血管测量资料。这项研究将探索两个主要的 假设探索了两个假设：1)CAVD和淀粉样β蛋白(Aβ)沉积是独立的预测因子 认知功能下降，CAVD增加通过干扰血管相关的 代偿机制；2)CAVD加速Aβ在脑内沉积，从而加速发病 临床症状。这项研究的结果将有助于我们进一步了解 血管病理与中年AD病理的关系。

Project-2 Summary/Abstract: The prevalence of Alzheimer's disease (AD) is closely related to the presence of cardiovascular disease (CaVD), understanding the relationship between AD pathology and CaVD is critically important. In the competing renewal of this Program Project (PPG3), we will explore whether our finding related to CaVD and Aβ pathology in a very elderly cohort will apply to a more diverse cohort. The overarching goal of Project 2 of PPG3 is to further the understanding of the relationship between AD pathology and midlife CaVD and the impact of these factors on cognitive impairment in a group of young old. To achieve these goals, we will utilize a group non-demented participants from an existing cohort from the ongoing community-based Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) study, a longitudinal study that began in 2003 with a cohort of 2000 participants (43% African American) between the ages of 45-75 years at study entry and has collected a wealth of longitudinal vascular measures. This study will explore two main hypotheses explore two hypotheses: 1) CaVD and amyloid-beta (Aβ) deposition are independent predictors of cognitive decline, and increased CaVD creates a state of vulnerability by interfering with vascular-related compensatory mechanisms; and 2) CaVD accelerates Aβ deposition in the brain, thus accelerating the onset of clinical symptoms. The findings from this study will help to further inform our understanding of the relationship between vascular pathology and AD pathology in midlife.