NRSA Training Core

NRSA 培训核心

• 批准号: 9261157
• 负责人: KAMRAN ATABAI
• 金额: $ 129.45万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-18 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9261157
• 关键词: Admission activity; Biological Products; Clinical; Clinical Research; Clinical Sciences; Dentistry; Development Plans; Discipline of Nursing; Doctor of Philosophy; Education; Ensure; Faculty; Goals; Health; Individual; Industry; Institutes; Internships; Lead; Leadership; Medicine; Mentors; National Research Service Awards; Paper; Perception; Pharmacy facility; Positioning Attribute; Postdoctoral Fellow; Process; Progress Reports; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Research Training; Schools; Science; Scientist; Students; TNFSF15 gene; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Work; abstracting; career; certificate program; experience; externship; medical schools; pre-doctoral; precision medicine; programs; skills; success

Contact PD/PI: Grandis, Jennifer Rubin NRSA-Training-001 (564) TL1 Abstract The fundamental goal of the UCSF Clinical and Translational Science Institute TL1 Training Program is to provide pre-doctoral and post-doctoral fellows with the methodological, analytic, leadership, and team science skills required to conduct transformative clinical and translational research relevant to precision health. To date, the Program has served only pre-doctoral fellows, who have co-authored 846 papers (2006-2014); 89% of trainees > 5 years following the TL1 experience report that they occupy academic positions; 89% report that the TL1 experience was worthwhile and influenced their commitment to a research career. The Program now proposes to expand to admit both pre-doctoral and post-doctoral clinical and PhD fellows, recruited from all 4 professional schools at UCSF (Medicine, Dentistry, Pharmacy and Nursing), with the following Aims: Aim 1. To enhance the highly successful TL1 program to train outstanding pre-doctoral professional students by creating a new 1-year training track that will allow them to obtain a Master's in Clinical Research; Aim 2. To stimulate UCSF pre-doctoral professional students to pursue careers as clinical and translational precision health researchers through short duration mentored research experiences; and Aim 3. To expand the Program to include 5 clinical and 5 PhD post-doctoral fellows per year, with the aim of enhancing their skills to ensure success as clinical and translational precision health researchers. All trainees will be supported by committees of their lead mentor and relevant co-mentors to help them devise and execute their individual development plans (IDP). All fellows will take didactic coursework supplemented by precision health-oriented coursework tailored to the IDP, carry out an individual precision health mentored research project, participate in bi-weekly faculty presentations and student-led works-in-progress, and have the option of pursuing internships or externships. This proposal aims to expand the successful pre-doctoral program, which confers an MD and Master's in Clinical Research in 5 years, to 8 year-long fellows. Four of these will be admitted to the TL1 Program concurrently with their medical school admissions process; an additional 4 fellows will be admitted after the first year of medical school. They will participate in TL1 activities after year 3 of medical school, and complete the required Advanced Training in Clinical Research (ATCR) Certificate Program and a Master's in Clinical Research by the end of the fifth year. Short-term pre-doctoral slots (3-4 months) will be offered to 10 professional students between years 1 and 2 of education, providing them with an intense introduction to clinical and translational precision health research. For the first time, the TL1 will provide precision health research training for 5 clinical and 5 PhD post-doctoral fellows with an emphasis on team science. Post- doctoral fellows will be required to complete the ATCR with the option to obtain the Master's. The TL1 will leverage UCSF's unique strengths and partnerships with basic scientists, biopharmaceutical investigators, and industry to position the fellows to advance Clinical and Translational Science related to precision health. Project Summary/Abstract Page 1496 Contact PD/PI: Grandis, Jennifer Rubin NRSA-Training-001 (564) References for J: TL1 1. Jameson JL and Longo DL. Precision Medicine—personalized,problematic, and promising. NEJM. 2015 Jun 4; 372(23):2229-34. PMID:26014593 2. Hawgood S, Hook-Barnard IG, O'Brien TC, Yamamoto KR. Precision medicine: Beyond the inflection point. Sci Transl Med. 2015 Aug 12; 7(300):300ps17. PMID:26268311 3. Nathan DG. Clinical research: perceptions, reality, and proposed solutions. National Institutes of Health Director's Panel on Clinical Research. JAMA. 1998 Oct 28;280(16):1427-31. PMID: 9801003 4. Nathan DG, Varmus HE. The National Institutes of Health and clinical research: a progress report. Nat Med 2000 Nov;6:1201-4. PMID:11062519 References Cited Page 1497

联系PD/PI：Grandis，Jennifer Rubin NRSA-Training-001（564） TL 1摘要 UCSF临床和转化科学研究所TL 1培训计划的基本目标是 为博士前和博士后研究员提供方法论，分析，领导力和团队科学 开展与精准健康相关的变革性临床和转化研究所需的技能。到 迄今为止，该计划只为博士前研究员提供服务，他们共同撰写了846篇论文（2006-2014）; 89% 在TL 1经历后> 5年的受训者报告说，他们担任学术职务; 89%的人报告说， TL 1的经历是值得的，并影响了他们对研究事业的承诺。该计划现在 建议扩大到招收博士前和博士后临床和博士研究员，从所有4个 UCSF的专业学校（医学，牙科，药学和护理），具有以下目标：目标1。到 加强非常成功的TL 1计划，通过创建培养优秀的博士前专业学生 一个新的为期1年的培训轨道，将使他们获得硕士学位的临床研究;目标2。刺激 UCSF博士前专业学生追求的职业生涯作为临床和翻译的精确健康 研究人员通过短期指导的研究经验;和目标3。为了扩大该计划， 包括每年5名临床和5名博士博士后研究员，目的是提高他们的技能，以确保 作为临床和转化精准健康研究人员的成功。所有学员将得到委员会的支持 他们的主要导师和相关的共同导师，以帮助他们设计和执行他们的个人发展 计划（IDP）。所有研究员都将参加教学课程，并辅以精确的健康导向课程 为IDP量身定制，开展个人精准健康指导研究项目，参加双周一次的 教师演示文稿和学生主导的工作在进行中，并有追求实习或 实习生该提案旨在扩大成功的博士预科课程，该课程授予MD和 5年内获得临床研究硕士学位，8年内获得研究员学位。其中四个将被接纳为TL 1 计划同时与他们的医学院录取过程;另外4名研究员将被录取 在医学院的第一年之后。他们将在医学院3年级后参加TL 1活动， 完成所需的临床研究高级培训（ATCR）证书课程和硕士学位， 临床研究到第五年年底。短期博士前插槽（3-4个月）将提供给10 专业学生之间的第1年和第2年的教育，为他们提供了一个激烈的介绍， 临床和转化精准健康研究。TL 1将首次提供精准健康 为5名临床和5名博士博士后研究员提供研究培训，重点是团队科学。后 博士研究员将被要求完成ATCR与选择获得硕士学位。TL 1将 利用UCSF的独特优势和与基础科学家，生物制药研究人员的伙伴关系， 行业定位研究员推进与精准健康相关的临床和转化科学。 项目摘要/摘要第1496页 联系PD/PI：Grandis，Jennifer Rubin NRSA-Training-001（564） J：TL 1的参考文献 1. Jameson JL和Longo DL.精准医疗-个性化，有问题，有前途。NEJM. 2015年6月4日; 372（23）：2229-34。PMID：26014593 2. Hawgood S，Hook-Barnard IG，奥布莱恩TC，山本KR.精准医疗：超越拐点 点Sci Transl Med. 2015年8月12日; 7（300）：300 ps17。PMID：26268311 3.内森·DG临床研究：感知、现实和建议的解决方案。国立卫生研究院 临床研究主任小组。JAMA. 1998年10月28日;280（16）：1427-31。PMID：9801003 4. Nathan DG，Varmus HE。美国国立卫生研究院和临床研究：进展报告。Nat 医学2000年11月;6：1201-4。PMID：11062519 第1497页引用