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Core B: Animal Models and Pathology

Core B: Animal Models and Pathology
核心 B：动物模型和病理学
批准号：
9072010
负责人：
Shikhar Mehrotra
金额：
$22.05万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
项目状态：
已结题
起止时间：
2016-05-01 至 2021-04-30
来源：
https://reporter.nih.gov/project-details/9072010
关键词：
AddressAnimal ModelAnimalsBiochemical PathwayBreedingCancer ModelCellsCeramidesCoupledDevelopmentEconomicsEmbryoEnsureEnzymesEquilibriumFibroblastsGenerationsGrowthHistologyHousingImmuneImmune systemIndividualInformation ResourcesLipidsMaintenanceMalignant NeoplasmsMediatingMetabolismMouse StrainsMusPathogenesisPathologyProgram Research Project GrantsQuality ControlRegulationResearchResearch PersonnelResearch Project GrantsResourcesRoleServicesSignal TransductionSolid NeoplasmSourceSphingolipidsTherapeuticTissue StainsTransducersTransgenic MiceTumor TissueVariantanti-cancer therapeuticcell growthcostin vivolipid metabolismmedical specialtiesnoveloperationpreclinical studyprogramsreceptorresearch studyresponsesphingosine 1-phosphatesphingosine kinasesphingosine-1-phosphate lyasetherapeutic targettrafficking

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SUMMARY The Animal Models and Pathology Core is established to provide essential animal and pathology resource components that comprehensively support research Projects utilizing animal models. The Specific Aims of this Core are: Specific Aim 1 - To maintain quality controlled breeding colonies for various mouse strains; Specific Aim 2 - To develop novel strains of transgenic mice and maintain breeding colonies of mice that will be specifically utilized by individual Projects in the Program; Specific Aim 3 - To generate mouse embryonic fibroblasts (MEFs) from various mice strains proposed in individual projects; Specific Aim 4 - To provide animal pathology services for in vivo cancer models; and Specific Aim 5 - To provide services for tumor tissue staining and characterization by IHC and TMA.
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Increasing Thiols for Improving T cell Immunotherapy
  • 批准号：
    10603006
  • 项目类别：
  • 资助金额：
    $39.42万
  • 财政年份：
    2022
  • 负责人：
    Shikhar Mehrotra
  • 依托单位：
    LIPO-IMMUNO TECH, LLC
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