Pathogenesis, Carcinogenesis and Ecology of Opisthorchiasis in Thailand

泰国阿片吸虫病的发病机制、致癌作用和生态学

• 批准号: 9112833
• 负责人: Banchob Sripa
• 金额: $ 30.74万
• 依托单位: KHON KAEN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9112833
• 关键词: Address; Adolescent; Adult; Anthelmintics; Behavioral; Bile duct carcinoma; Biliary; Biometry; Cambodia; Canis familiaris; Carcinogens; Cells; Cessation of life; China; Cholangiocarcinoma; Chronic; Clonorchis sinensis; Communities; Consumption; Country; Development; Diet; Disease; Duodenum; Eating; Ecology; Environment; Environmental Impact; Epidemiology; Epithelium; Fasciola hepatica; Felis catus; Fibrosis; Fishes; Fresh Water; Genetic; Genotype; Goals; Health education; Host-Parasite Relations; Human; Incidence; Individual; Infection; Infection Control; Inflammatory; Ingestion; International Agency for Research on Cancer; Intervention; Korea; Laboratories; Laos; Light; Liver; Liver Fibrosis; Maintenance; Malignant Neoplasms; Malignant neoplasm of liver; Modeling; Molecular; Molecular Carcinogenesis; Morbidity - disease rate; New York; Opisthorchiasis; Opisthorchis viverrini; Parasites; Parasitology; Pathogenesis; Pattern; Persons; Pharmaceutical Preparations; Pharmacologic Substance; Population; Praziquantel; Predisposition; Prevalence; Property; Proteins; Province; Public Health; Reporting; Research; Research Personnel; Risk; Rural; Skin; Snails; Southeastern Asia; Staging; Strategic Planning; Stream; Thailand; Time; Trematoda; Uncertainty; Vietnam; Work; World Health Organization; bile duct; biliary tract; burden of illness; carcinogenesis; cholangiocyte; design; egg; human disease; neglected tropical diseases; phenotypic biomarker; programs; transmission process; tumor; tumorigenic; uncooked; undercooked

This TMRC application deals with the neglected tropical disease, opisthorchiasis, caused by infection with the fish-borne trematode parasite, Opisthorchis viverrini. Chronic opisthorchiasis often culminates cholangiocarcinoma, cancer of the bile ducts. This TMRC application takes place in Khon Kaen Province, on the Khorat Plateau in northeastern Thailand. The research draws together a diverse team of researchers with expertise in carcinogenesis, molecular and immuno-parasitology, pathogenesis, biostatistics, epidemiology and transmission modeling. The proposed research, which includes three scientific projects and two cores, addresses major gaps in our current understanding of carcinogenesis, host-susceptibility and the ecology of O. viverrini transmission. While our research focuses specifically on O. viverrini, the research has implications for the control of other carcinogenic liver flukes, particularly, Clonorchis sinensis. Together, these parasites infec an estimated 45 million people in Southeast Asia, China and the Koreas, with infections and associated malignancies concentrated in the rural poor. The proposal includes three scientific projects and two cores. The scientific goals of this TMRC involve characterizing human phenotypic markers displayed by infected humans who are at risk of cholangiocarcinoma caused by O. viverrini. In particular, we will compare and contrast immunological and inflammatory profiles of individuals whose liver (periportal) fibrosis do or does not resolve after medication with praziquantel to remove the parasite infection. These comparisons can be predicted to deliver markers that predict progression to advanced liver fibrosis and indeed cholangiocarcinoma from among the millions of persons infected with O. viverrini, and perhaps also from the many millions more infected with related liver flukes, including Clonorchis sinensis in Vietnam, China and the Koreas.

这份热带病防治资源中心的申请涉及被忽视的热带病-后睾吸虫病，这种疾病是由鱼传吸虫寄生虫-猫尾后睾吸虫感染引起的。慢性后睾吸虫病常导致胆管癌，胆管癌。这次TMRC的申请发生在泰国东北部呼罗珊高原的孔敬省。该研究汇集了一个多元化的研究团队，他们在致癌作用，分子和免疫寄生虫学，发病机制，生物统计学，流行病学和传播建模方面具有专业知识。这项拟议中的研究包括三个科学项目和两个核心，解决了我们目前对致癌作用、宿主易感性和O. Viverrini传播。我们的研究主要集中在O.因此，该研究对控制其他致癌性肝吸虫，特别是华支睾吸虫，具有一定的意义。这些寄生虫感染了东南亚、中国和韩国约4500万人，感染和相关恶性肿瘤集中在农村贫困人口中。 该提案包括三个科学项目和两个核心。该TMRC的科学目标包括表征受感染的人所显示的人类表型标记，这些人具有由O.维韦里尼。特别是，我们将比较和对比免疫和炎症个人的肝脏（门静脉周围）纤维化做或不解决后，吡喹酮药物治疗，以消除寄生虫感染。这些比较可以预测提供的标志物，预测进展到先进的肝纤维化，甚至胆管癌从数以百万计的人感染O。可能还有数百万人感染了相关的肝吸虫，包括越南、中国和韩国的华支睾吸虫。