Rare Central Nervous System Cancers Initiative
罕见中枢神经系统癌症倡议
基本信息
- 批准号:9344012
- 负责人:
- 金额:$ 39.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:AdultBrain Stem GliomaBrain Stem NeoplasmsCaregiversCentral Nervous System NeoplasmsChildhoodChordomaChoroid Plexus CarcinomaClassificationClinical TrialsCollaborationsConsensusDiffuse intrinsic pontine gliomaDiseaseEpendymomaEvaluationFundingGenomic DNAGenomicsGlioblastomaGliomaGliomatosis cerebriImageImaging technologyImmunologic MonitoringImmunotherapyIncidenceInternationalInvestigationKnowledgeLaboratoriesMalignant - descriptorMalignant NeoplasmsMalignant neoplasm of central nervous systemMolecularMonitorMonographMutationNational Cancer InstituteNatural HistoryNeoplasmsNeuraxisNormal tissue morphologyOligodendroglioma-AstrocytomaPathogenesisPatient ParticipationPatientsPrimary Brain NeoplasmsPrimary NeoplasmProteomicsPublishingQualifyingRare DiseasesRegimenResearchResearch InfrastructureResearch PersonnelResourcesRhabdoid TumorSystemTestingTherapeuticTissuesTumor BiologyTumor TissueUnited StatesUnited States National Institutes of Healthbaseclinical infrastructuredata managementimaging biomarkerimprovedmedulloblastomametabolomicsoutreachpatient advocacy grouppineoblastomapredicting responseprognosticprogramsrepositoryresponsetumor
项目摘要
The NIH is uniquely suited to create a rare CNS cancer initiative. This effort will utilize the following specific resources of the NIH. This has required developing a clinical trial infrastructure, including data management system, to oversee the disease specific therapeutic and natural history studies. Collaborations with experts in imaging technologies to create imaging biomarkers and routine imaging for monitoring response to therapies. This initiative will combine the expertise from both pediatric and adult investigators, benefitting from the varied approaches from these investigators. A tissue repository has been developed to store both tumor and normal tissue for molecular analyses including genomics, metabolomics, and proteomics with the intent of advancing the understanding of tumor biology and pathogenesis leading to better prognostic information, sub-classification and ultimately markers predictive of response to specific treatments. Additionally, specific testing capabilities will be established based on project need. For example, an immunotherapy trial is anticipated and immunologic monitoring capabilities will be needed as a critical component of this study. NIH-based outreach efforts will be utilized to interact with patient advocacy groups to enhance patient participation in these efforts and provide a venue for educational programs to improve patient and caregiver understanding of their uncommon disease.
NIH是唯一适合创建一个罕见的中枢神经系统癌症倡议。这项工作将利用NIH的以下具体资源。这需要开发临床试验基础设施,包括数据管理系统,以监督疾病特异性治疗和自然史研究。与成像技术专家合作,创建成像生物标志物和常规成像,以监测对治疗的反应。该计划将联合收割机结合儿科和成人研究者的专业知识,从这些研究者的各种方法中受益。已经开发了组织储存库以存储肿瘤和正常组织用于分子分析,包括基因组学、代谢组学和蛋白质组学,目的是促进对肿瘤生物学和发病机制的理解,从而产生更好的预后信息、子分类和最终预测对特定治疗的反应的标志物。此外,将根据项目需要建立特定的测试能力。例如,预计将进行免疫治疗试验,免疫监测能力将作为本研究的关键组成部分。基于NIH的外展工作将用于与患者倡导团体互动,以提高患者对这些工作的参与,并为教育计划提供场所,以提高患者和护理人员对其罕见疾病的了解。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mark Gilbert其他文献
Mark Gilbert的其他文献
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{{ truncateString('Mark Gilbert', 18)}}的其他基金
Exploring the Therapeutic Potential of Stem Cell Biology in Gliomas
探索干细胞生物学在神经胶质瘤中的治疗潜力
- 批准号:
10014742 - 财政年份:
- 资助金额:
$ 39.33万 - 项目类别:
Identifying New Glioma-Associated Tumor Suppressors and Oncogenes
鉴定新的神经胶质瘤相关肿瘤抑制因子和癌基因
- 批准号:
10014745 - 财政年份:
- 资助金额:
$ 39.33万 - 项目类别:
Exploring the Therapeutic Potential of Stem Cell Biology in Gliomas
探索干细胞生物学在神经胶质瘤中的治疗潜力
- 批准号:
10262378 - 财政年份:
- 资助金额:
$ 39.33万 - 项目类别:
Brain Tumor Animal Therapeutics Core (Scientific Cores)
脑肿瘤动物治疗核心(科学核心)
- 批准号:
9154353 - 财政年份:
- 资助金额:
$ 39.33万 - 项目类别:
Identifying New Glioma-Associated Tumor Suppressors and Oncogenes
鉴定新的神经胶质瘤相关肿瘤抑制因子和癌基因
- 批准号:
10486899 - 财政年份:
- 资助金额:
$ 39.33万 - 项目类别: