The Administrative Core of the Center for SUDEP Research

SUDEP研究中心的行政核心

• 批准号: 9146976
• 负责人: Samden Lhatoo
• 金额: $ 55.86万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9146976
• 关键词: American; Animals; Area; Autistic Disorder; Award; Awareness; Benchmarking; Biochemical; Brain; Brain Stem; Cardiovascular system; Cessation of life; Chicago; Childhood; Clinical; Clinical Sciences; Collaborations; Communication; DNA; Data; Data Analytics; Data Protection; Databases; Development; Electronic Mail; Electrophysiology (science); Fostering; Foundations; Funding; Genetic; Grant; Health; Human; Illinois; Informatics; Institutes; Knowledge; Leadership; London; Mediating; Mentorship; Mission; Monitor; National Institute of Neurological Disorders and Stroke; Neuromodulator; Neurotransmitters; New York; Oregon; Patients; Phase; Physiological; Predisposition; Prevention; Procedures; Progress Reports; Protocols documentation; Public Health; Publishing; Qualifying; Registries; Reporting; Research; Research Activity; Research Infrastructure; Research Institute; Research Personnel; Research Priority; Resources; Respiratory Process; Risk; Role; Sampling; Scientist; Seizures; Sudden Death; Surveys; Systems Biology; Teleconferences; Texas; Translational Research; Universities; Vision; Writing; base; biobank; college; data sharing; imaging genetics; meetings; mortality; neuropathology; programs; sudden unexpected death in epilepsy; trend

 DESCRIPTION (provided by applicant): Emerging evidence points to a "perfect storm" of profound, deleterious, seizure-driven suprapontine effects on brainstem-mediated cardiovascular and respiratory processes leading to Sudden Unexpected Death in Epilepsy (SUDEP). This fatal dysregulation is likely to be underpinned by structural (pre-existing seizure- damaged autonomic regulatory areas) and functional (neurotransmitter/neuromodulator) predispositions. A multi-disciplinary Center Without Walls (CWW), systems biology-based approach that assembles and leverages clinical, electrophysiological, biochemical, imaging, genetic and neuropathological expertise has the best potential to unlock SUDEP mechanisms and the role of suprapontine influences. The NINDS funded the Prevention and Risk Identification of SUDEP Mortality (PRISM) Project through exploratory grant 1P20- NS076965. The SUDEP Translational Research Alliance (SUTRA) is the next phase of PRISM and is a multi-center, multi-disciplinary consortium led by Case Western Reserve University and includes UCLA, Northwestern University in Chicago, New York University, Southern Illinois University, Legacy Research Institute, Oregon, University College London, University of North Texas and Columbia University. PRISM has built infrastructure, resources and protocols, and established genetics (203 SUDEP DNA samples), neuropathology (139 SUDEP brains) and multimodal seizure data repositories on >300 prospectively surveyed patients. We have generated preliminary genetic, neuropathology and physiological seizure data to leverage the hypothesis driven scientific projects of this application. The primary mission of the SUTRA Administrative Core is to oversee, co-ordinate, prioritize and facilitate CWW research activities and functioning. The organized plan will comprise an Informatics and Data Analytics Core and five scientific project U01s. Specific Aims for SUTRA are 1) to provide overall leadership, vision, expertise and direction in the CWW's mission of research, discovery and dissemination of new knowledge, through establishment and implementation of the SUTRA charter and regular review and revision of direction, 2) to facilitate communications and collaborations between Cores and research groups participating in SUTRA, 3) to report all Center activities and progress to NINDS, the Executive and Steering Committees and 4) to further develop and expand SUTRA research infrastructure (expanding its biorepositories, establishing a Pilot and Feasibility Program, a Mentorship Program and an Enrichment Program to foster awareness of the latest research trends and opportunities). SUTRA will optimize and streamline interfaces with local resources and national resources including Epi4K, Autism Brain Net, the North American SUDEP Registry, the SUDEP Institute and the Sudden Death in Childhood Program.

 描述（由申请人提供）：新出现的证据表明，脑干介导的心血管和呼吸过程受到深刻、有害、癫痫驱动的桥上效应的“完美风暴”，导致癫痫性猝死（SUDEP）。这种致命的失调可能是由结构性（预先存在的癫痫发作受损的自主神经调节区域）和功能性（神经递质/神经调节剂）倾向所支撑的。多学科无墙中心 (CWW)、基于系统生物学的方法汇集和利用临床、电生理学、生化、成像、遗传和神经病理学专业知识，最有潜力解开 SUDEP 机制和桥上影响的作用。 NINDS 通过探索性拨款 1P20-NS076965 资助了 SUDEP 死亡率预防和风险识别 (PRISM) 项目。 SUDEP 转化研究联盟 (SUTRA) 是 PRISM 的下一阶段，是一个由凯斯西储大学领导的多中心、多学科联盟，成员包括加州大学洛杉矶分校、芝加哥西北大学、纽约大学、南伊利诺伊大学、俄勒冈州遗产研究所、伦敦大学学院、北德克萨斯大学和哥伦比亚大学。 PRISM 已经建立了基础设施、资源和协议，并为超过 300 名前瞻性调查的患者建立了遗传学（203 个 SUDEP DNA 样本）、神经病理学（139 个 SUDEP 大脑）和多模式癫痫数据存储库。我们已经生成了初步的遗传、神经病理学和生理癫痫数据，以利用该应用程序的假设驱动的科学项目。 SUTRA 行政核心的主要任务是监督、协调、确定优先顺序并促进 CWW 研究活动和运作。 该计划将包括一个信息学和数据分析核心以及五个科学项目 U01。 SUTRA 的具体目标是 1) 通过制定和实施 SUTRA 章程以及定期审查和修订方向，为 CWW 的研究、发现和传播新知识的使命提供总体领导、愿景、专业知识和方向，2) 促进参与 SUTRA 的核心和研究小组之间的沟通和合作，3) 向 NINDS、执行和指导委员会报告所有中心活动和进展，4) 进一步发展和扩大 SUTRA 研究基础设施（扩大其生物样本库、建立试点和可行性计划、指导计划和丰富计划，以提高对最新研究趋势和机会的认识）。 SUTRA 将优化和简化与当地资源和国家资源的接口，包括 Epi4K、Autism Brain Net、北美 SUDEP 登记处、SUDEP 研究所和儿童猝死项目。