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New methods for the modification of peptides and proteins with the Re(CO)3 moiety

用 Re(CO)3 部分修饰肽和蛋白质的新方法

基本信息

批准号：
9096321
负责人：
CHRISTOPHER J ZIEGLER
金额：
$ 39.27万
依托单位：
UNIVERSITY OF AKRON
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2020-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9096321
关键词：
Alcohols Amines Amino Acids Area Binding Biochemical Biological Carbon Carbon Monoxide Chemicals Chemistry Complex Development Diagnosis Disease Doctor of Philosophy Environment Face Funding Goals Grant Health Histidine Hydrogen Bonding Imidazole Institution Investigation Joints Label Laboratories Ligand Binding Ligands Location Metals Methodology Methods Modeling Modification Muramidase Organometallic Chemistry Organometallic Compounds Peptides Pharmaceutical Preparations Pharmacologic Substance Positioning Attribute Post-Translational Protein Processing Property Protein Dynamics Proteins Radioisotopes Reaction Reagent Research Research Personnel Research Support Rhenium Schiff Bases Side Site Structure Sulfhydryl Compounds System Techniques Testing Time Training Universities Vertebral column Work adduct analog base biological systems catalyst college complex biological systems functional group graduate student high reward high risk imaging agent inhibitor/antagonist innovation interest macromolecule method development polypeptide programs public health relevance scaffold synthetic peptide undergraduate student

项目摘要

DESCRIPTION (provided by applicant): The organometallic functionalization of biological molecules has increased in importance as researchers have found new uses for organometallic compounds as probes for protein dynamics, as possible pharmaceuticals and imaging agents, and as green catalysts for organic transformations. In spite of this interest, there are few synthetic methods for the functionalization of proteins and peptides with organometallic groups, with most of the chemistry focusing on direct binding to amino acid side chain groups like histidine. This proposal will present a plan to expand the reaction chemistry used to make organometallic protein and peptide conjugates, with a focus on the chemistry of Re(CO)3 compounds. The three aims to the strategy outlined in the proposal are: Developing synthetic methodologies for making rhenium-modified peptides, new techniques for modifying proteins with rhenium, and rhenium-centered synthetic amino acids and peptides: This work is a collaborative project between a Ph.D. granting institution and an undergraduate institution. This work will be carried out in two locations: in the laboratories of Prof. Christopher J. Ziegler at te University of Akron, as well as in the laboratories of Prof. Richard Herrick at the College of the Holy Cross. In addition to supporting the research program, funds from this grant will be used to train undergraduate and graduate students in synthetic inorganic and biochemical methods, and will enhance the research environment at the University of Akron and the College of the Holy Cross.