REPOSITORY SERVICES FOR OFFSPRING GENOME WIDE DNA METHYLATION PATTERNS AT BIRTH AND THE INTRAUTERINE ENVIRONMENT IN THE EAGeR TRIAL (EAGeR EWAS)

EGeR 试验 (EGeR EWAS) 中的后代出生时全基因组 DNA 甲基化模式和宫内环境的存储库服务

• 批准号: 9325096
• 金额: $ 0.22万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-23 至 2024-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9325096
• 关键词: Antioxidants; Aspirin; Biological Assay; Birth; Blood flow; Conceptions; DNA; DNA Methylation; Dose; Double-Blind Method; Enrollment; Environment; Epigenetic Process; Fetal Growth; Inflammation; Methylation; Monitor; Nutrient; Obesity; Oxidative Stress; Oxygen; Pattern; Perfusion; Placebos; Play; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy loss; Property; Role; Sampling; Services; Shipping; Ships; Site; Specimen; Testing; Tissue Sample; Urine; Vascular resistance; Woman; Women' s Group; epigenome-wide association studies; experience; genome-wide; implantation; improved; offspring; perinatal outcomes; randomized trial; repository; trial design

The EAGeR study is a multi-site, double-blinded randomized trial designed to assess the effects of low-dose aspirin on implantation and pregnancy outcome. It is the largest such study to-date, enrolling 1,228 (535 in the low-dose aspirin group and 543 in the placebo group) women experiencing a recent pregnancy loss who are planning subsequent pregnancies. Daily urine samples were collected to monitor very early pregnancy and pregnancy loss. Pregnancy loss, pregnancy complications and perinatal outcomes were monitored throughout pregnancy. We hypothesized that low-dose aspirin may reduce oxidative stress and inflammation and, therefore, reduce vascular resistance and improve blood flow and placental perfusion. Aspirin might have antioxidant properties and plays an important role in inflammation. It will be the largest such study to-date, enrolling 1,600 women experiencing a recent pregnancy loss who are planning subsequent pregnancies. We hypothesize that low-dose aspirin may reduce oxidative stress and inflammation and, therefore, reduce vascular resistance and improve blood flow and placental perfusion. An increased supply of oxygen and nutrients should promote placental and fetal growth, enhance conception rates, reduce pregnancy loss and pregnancy complications and, thereby, improve perinatal outcomes. Findings from this trial will have important implications not only for women trying to conceive but also for women who want to maintain a healthy pregnancy and achieve optimal perinatal outcomes. Supports Z1AHD008795

EAGeR研究是一项多中心、双盲随机试验，旨在评估低剂量阿司匹林对着床和妊娠结局的影响。这是迄今为止规模最大的此类研究，招募了1，228名（低剂量阿司匹林组535名，安慰剂组543名）近期妊娠失败并计划再次妊娠的女性。每天收集尿液样本，以监测极早期妊娠和妊娠丢失。在整个妊娠期间监测妊娠丢失、妊娠并发症和围产期结局。我们假设低剂量阿司匹林可以减少氧化应激和炎症，从而降低血管阻力并改善血流和胎盘灌注。 阿司匹林可能具有抗氧化特性，在炎症中起着重要作用。这将是迄今为止规模最大的此类研究，招募了1，600名最近怀孕失败并计划再次怀孕的女性。我们推测，低剂量阿司匹林可以减少氧化应激和炎症，因此，减少血管阻力，改善血流和胎盘灌注。增加氧气和营养的供应应促进胎盘和胎儿生长，提高受孕率，减少流产和妊娠并发症，从而改善围产期结果。这项试验的结果不仅对试图怀孕的女性，而且对想要保持健康怀孕并实现最佳围产期结局的女性都将产生重要影响。支持Z1AHD008795