Identification of Inhibitors of human Lactate Dehydrogenase A (LDHA) as Anti-cancer Agents

项目亮点：筛选了完整的化合物库，并确定了一个先导化学型用于开发。药物化学正在改善LDHA抑制活性，并且正在进行一系列先进的分析来表征这些化合物的细胞活性，并支持主要候选药物的临床前进展。

Project highlights: the full compound library was screened and a lead chemotype was identified for development. Medicinal chemistry is ongoing to improve LDHA inhibitory activity, and a battery of advanced assays are in progress to characterize cellular activity of these compounds and support preclinical advancement of a lead candidate. During this period, the NCGC has fostered and maintained over 180 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to over 100 high-throughput screens and nearly 60 medicinal chemistry campaigns, providing our collaborators and the general research community a wealth of publications and promising small molecule leads. In addition, the NCGC has undertaken a number of informatic challenges to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.