Socio-emotional dysfunction in schizophrenia and bipolar disorders: Facial, voca

精神分裂症和双相情感障碍的社会情感功能障碍：面部、声音

• 批准号: 9108401
• 负责人: Yu-Han Chen
• 金额: $ 20.07万
• 依托单位: THE MIND RESEARCH NETWORK
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9108401
• 关键词: Amygdaloid structure; Anatomy; Anisotropy; Area; Auditory; Biological Neural Networks; Bipolar Disorder; Brain; Cognitive; Data; Data Set; Development; Diagnosis; Diffusion Magnetic Resonance Imaging; Disease; Emotional; Emotions; Face; Friendships; Functional disorder; Group Processes; Impairment; Individual; Insula of Reil; Knowledge; Left; Link; Magnetoencephalography; Measures; Mediating; Moods; Multimodal Imaging; Occupational; Patients; Pattern; Performance; Population; Process; Research; Resolution; Schizophrenia; Sensory; Social Functioning; Social Work; Societies; Source; Staging; Stimulus; Structure; Superior temporal gyrus; Testing; Training Programs; Work; area striata; associated symptom; base; experience; functional outcomes; fusiform face area; millisecond; neuroimaging; neuropsychiatric disorder; novel; psychopharmacologic; psychosocial; relating to nervous system; social; social cognition; social skills; white matter

Impaired socio-emotional (SE) functioning is a prominent feature of schizophrenia (SZ), especially the ability to perceive emotion in faces and prosody. Conceivably, such deficits result in difficulties integrating into society and thus maintaining friendships and relationships at work. Compared to other psychiatric population such as bipolar disorder (BP), SZ patients experience greater impairments in SE functioning and poorer functional outcome than BP patients. Therefore, understanding how deficits in SE neurocircuitry contribute to different levels of social and occupational functioning in SZ relative to BP and healthy controls (HC) can provide important knowledge for developing specific training programs and treatments that target different psychiatric populations. This project will apply multimodal neuroimaging - Magnetoencephalography (MEG) and Diffusion Tensor Imaging (DTI) - to assess the underlying mechanisms of altered SE functioning in SZ and BP patients. MEG'S unique combination of temporal and spatial resolution, in combination with structural MRl (sMRI), provides information on brain processes occurring millisecond by millisecond and is able to evaluate top-down and bottom-up emotional processing at different stages. DTI adds complementary information about how white matter integrity contributes to deficits at different stages of emotion processing. To better understand how SE impairment mediates social functioning in SZ, the proposed research will (1) evaluate the SE neural networks unique to and shared in SZ and BP by measuring brain activity and structures associated with SE processing via the use of MEG, sMRI, and DTI; (2) evaluate the social functioning differences between SZ and BP by assessing the ability to perceive emotion and the ability to integrate social skills in society using cognitive and psychosocial measures; and (3) evaluate associations between neural networks and associated anatomy and performance on psychosocial and social functioning measures. Together, the aims of this project will provide a novel dataset that will elucidate the common and unique aspects of SE functioning in SZ, BP, and HC.

社会情绪（SE）功能受损是精神分裂症（SZ）的一个突出特征，特别是 通过面部表情和韵律来感知情感。可以想象，这种赤字会导致难以融入社会 从而在工作中保持友谊和关系。与其他精神病患者相比， 双相情感障碍（BP），SZ患者的SE功能受损更严重， 结果BP患者。因此，了解SE神经回路的缺陷如何导致不同的 SZ相对于BP和健康对照（HC）的社会和职业功能水平可以提供 制定针对不同精神疾病的特定培训计划和治疗的重要知识 人口。该项目将应用多模式神经成像-脑磁图（MEG）和弥散 张量成像（DTI）-评估SZ和BP患者SE功能改变的潜在机制。 MEG的时间和空间分辨率的独特组合，与结构MRI（sMRI）相结合， 提供了关于大脑过程的信息，并能够自上而下地评估 以及不同阶段的自下而上的情绪处理。DTI添加了有关白色如何的补充信息 物质完整性会导致情绪处理不同阶段的缺陷。为了更好地了解SE 损伤介导的社会功能在SZ，拟议的研究将（1）评估SE神经网络 通过测量与SE处理相关的大脑活动和结构， 通过使用MEG，sMRI和DTI;（2）通过以下方式评估SZ和BP之间的社会功能差异： 评估感知情绪的能力和使用认知和社会整合社交技能的能力， 社会心理测量;以及（3）评估神经网络与相关解剖结构之间的关联， 社会心理和社会功能指标的表现。总之，该项目的目标将提供一个 新的数据集，将阐明在SZ，BP和HC中SE功能的共同和独特方面。