Identification of Small Molecules with INF-beta Inducing Properties as Anti-Viral Leads

鉴定具有 INF-β 诱导特性的小分子作为抗病毒先导药物

• 批准号: 9360483
• 负责人: Ajit Jadhav
• 金额: $ 3.75万
• 依托单位: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9360483
• 关键词: Antiviral Agents; Antiviral Therapy; Biology; Cells; Chemicals; Collaborations; Communities; Development; Disease; Extramural Activities; Fostering; General Population; Genomics; Goals; Human; Informatics; Interferon-beta; Lead; Modeling; Pharmaceutical Chemistry; Pharmaceutical Preparations; Process; Property; Publications; Research; Research Personnel; Resources; Signaling Protein; Synthesis Chemistry; United States National Institutes of Health; Validation; Viral; Work; assay development; base; drug development; drug discovery; high throughput screening; human disease; improved; new technology; novel therapeutics; screening; small molecule; small molecule therapeutics; therapeutic development; tool

During this period, the NCGC worked to further characterize previously identified hits. As a center, the NCGC has fostered and maintained over 110 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to dozens of high-throughput screens and a number of medicinal chemistry campaigns to further improve on screening hits, providing our collaborators and the general research community with publications and a variety of promising small molecule probes and leads. In addition, the NCGC has worked to advance a number of informatic initiatives to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.

在此期间，NCGC努力进一步描述先前确定的命中。