IGF::OT::IGF AMERICAN TYPE CULTURE COLLECTION:1108663 [16-063189]

为了满足对更好的癌症研究工具的需求，NCI的癌症基因组学办公室(OCG)、癌症基因组学中心与国际机构建立了一个联盟，即人类癌症模型倡议(HCMI)。HCMI的目标是向科学界提供来自最多12个器官的大量“下一代”体外癌症模型，这些器官不会受到过度的知识产权(IP)限制。来自学术、工业和/或非营利性组织的科学家将广泛获取体外癌症模型以及临床和分子特征数据。这些模型、从中衍生出来的肿瘤和匹配的“正常”组织将通过测序来表征。 此任务订单旨在资助一家供应商分发由三种或更多不同技术生成的100个“下一代”癌症模型，以测试该过程：1.从生成模型的实验室获取冷冻培养；2.鉴定、生产、保存、开发、评估质量保证；3.在全球分发模型和信息，以支持生命科学中的高质量研究。经销商应准备好与最多12个器官部位的模型合作。预计在未来，分销商将为研究界提供这项活动。

To address the need for better tools to study cancer, NCI’s Office of Cancer Genomics (OCG), Center for Cancer Genomics, together with international institutions, has established a consortium, the Human Cancer Models Initiative (HCMI). HCMI’s goal is to make available to the scientific community large numbers of “next generation” in vitro cancer models from up to twelve organs that are not encumbered with excessive intellectual property (IP) constraints. The in vitro cancer models and the clinical and molecular characterization data will be broadly accessible to scientists from academic, industry, and/or non-profit organizations. The models, the tumor from which they are derived, and matched “normal” tissue will be characterized by sequencing. This task order aims to fund one vendor to distribute 100 “next generation” cancer models generated by three or more different technologies to test the process to 1. acquire frozen cultures from the laboratories which generate the models, 2. authenticate, produce, preserve, develop, evaluate quality for quality assurance and 3. distribute globally the models and information to support high quality research in the life sciences. The distributor should be ready to work with models from up to 12 organ sites. It is expected that in the future, the distributor would provide this activity for the benefit of the research community.