IGF::OT::IGF AMERICAN TYPE CULTURE COLLECTION:1108663 [16-063189]

为了满足对更好的癌症研究工具的需求，NCI的癌症基因组学办公室（OCG），癌症基因组学中心与国际机构一起建立了一个联盟，即人类癌症模型倡议（HCMI）。 HCMI的目标是为科学界提供大量的“下一代”体外癌症模型，这些模型来自多达12个器官，并且不受过度的知识产权（IP）限制。 体外癌症模型以及临床和分子表征数据将广泛提供给来自学术，工业和/或非营利组织的科学家。 这些模型、它们所来源的肿瘤和匹配的“正常”组织将通过测序来表征。 该任务订单旨在资助一家供应商分发100个由三种或更多种不同技术生成的“下一代”癌症模型，以测试1。从生成模型的实验室获得冷冻培养物，2.认证、生产、保存、开发、评估质量以保证质量; 3.在全球范围内分发模型和信息，以支持生命科学领域的高质量研究。 经销商应准备好与来自多达12个器官部位的模型合作。 预计今后，分销商将为研究界提供这一活动。

To address the need for better tools to study cancer, NCI’s Office of Cancer Genomics (OCG), Center for Cancer Genomics, together with international institutions, has established a consortium, the Human Cancer Models Initiative (HCMI). HCMI’s goal is to make available to the scientific community large numbers of “next generation” in vitro cancer models from up to twelve organs that are not encumbered with excessive intellectual property (IP) constraints. The in vitro cancer models and the clinical and molecular characterization data will be broadly accessible to scientists from academic, industry, and/or non-profit organizations. The models, the tumor from which they are derived, and matched “normal” tissue will be characterized by sequencing. This task order aims to fund one vendor to distribute 100 “next generation” cancer models generated by three or more different technologies to test the process to 1. acquire frozen cultures from the laboratories which generate the models, 2. authenticate, produce, preserve, develop, evaluate quality for quality assurance and 3. distribute globally the models and information to support high quality research in the life sciences. The distributor should be ready to work with models from up to 12 organ sites. It is expected that in the future, the distributor would provide this activity for the benefit of the research community.