IGF::OT::IGF AMERICAN TYPE CULTURE COLLECTION:1108663 [16-063189]

IGF::OT::IGF 美国型培养物收藏：1108663 [16-063189]

• 批准号: 9364774
• 负责人: RONALD HART
• 金额: $ 215.1万
• 依托单位: AMERICAN TYPE CULTURE COLLECTION
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2018-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9364774
• 关键词: Address; American Type Culture Collection; Biological Sciences; Cancer Model; Clinical; Communities; Data; Freezing; Funding; Future; Goals; Human; In Vitro; Industry; Institution; Intellectual Property; International; Laboratory culture; Malignant Neoplasms; Modeling; Molecular; Nonprofit Organizations; Normal tissue morphology; Office of Cancer Genomics; Organ; Process; Research; Scientist; Site; Technology; Testing; Vendor; Work; cancer genomics; information model; next generation; quality assurance; tool; tumor

To address the need for better tools to study cancer, NCI’s Office of Cancer Genomics (OCG), Center for Cancer Genomics, together with international institutions, has established a consortium, the Human Cancer Models Initiative (HCMI). HCMI’s goal is to make available to the scientific community large numbers of “next generation” in vitro cancer models from up to twelve organs that are not encumbered with excessive intellectual property (IP) constraints. The in vitro cancer models and the clinical and molecular characterization data will be broadly accessible to scientists from academic, industry, and/or non-profit organizations. The models, the tumor from which they are derived, and matched “normal” tissue will be characterized by sequencing. This task order aims to fund one vendor to distribute 100 “next generation” cancer models generated by three or more different technologies to test the process to 1. acquire frozen cultures from the laboratories which generate the models, 2. authenticate, produce, preserve, develop, evaluate quality for quality assurance and 3. distribute globally the models and information to support high quality research in the life sciences. The distributor should be ready to work with models from up to 12 organ sites. It is expected that in the future, the distributor would provide this activity for the benefit of the research community.

为了满足对更好的癌症研究工具的需求，NCI 癌症基因组学办公室 (OCG)、癌症基因组学中心与国际机构一起建立了一个联盟，即人类癌症模型计划 (HCMI)。 HCMI 的目标是向科学界提供来自多达 12 个不受过度知识产权 (IP) 限制的器官的大量“下一代”体外癌症模型。 来自学术界、工业界和/或非营利组织的科学家将可以广泛获取体外癌症模型以及临床和分子表征数据。 这些模型、其来源的肿瘤以及匹配的“正常”组织将通过测序来表征。 该任务订单旨在资助一家供应商分发 100 个由三种或多种不同技术生成的“下一代”癌症模型，以测试以下过程：1. 从生成模型的实验室获取冷冻培养物，2. 验证、生产、保存、开发、评估质量以保证质量，3. 在全球范围内分发模型和信息，以支持生命科学研究的高质量研究。 经销商应准备好使用来自多达 12 个器官部位的模型。 预计将来经销商将提供这项活动，以造福研究界。