IGF::OT::IGF AMERICAN TYPE CULTURE COLLECTION:1108663 [16-063189]

为了解决对更好的癌症研究工具的需求，NCI的癌症基因组学办公室（OCG）、癌症基因组学中心与国际机构一起建立了一个联盟，即人类癌症模型倡议（HCMI）。HCMI的目标是向科学界提供大量来自多达12个器官的“下一代”体外癌症模型，这些模型不会受到过多的知识产权（IP）限制。体外癌症模型以及临床和分子表征数据将广泛地提供给来自学术界、工业界和/或非营利组织的科学家。这些模型，它们来源于的肿瘤，以及匹配的“正常”组织将通过测序来表征。

To address the need for better tools to study cancer, NCI’s Office of Cancer Genomics (OCG), Center for Cancer Genomics, together with international institutions, has established a consortium, the Human Cancer Models Initiative (HCMI). HCMI’s goal is to make available to the scientific community large numbers of “next generation” in vitro cancer models from up to twelve organs that are not encumbered with excessive intellectual property (IP) constraints. The in vitro cancer models and the clinical and molecular characterization data will be broadly accessible to scientists from academic, industry, and/or non-profit organizations. The models, the tumor from which they are derived, and matched “normal” tissue will be characterized by sequencing. This task order aims to fund one vendor to distribute 100 “next generation” cancer models generated by three or more different technologies to test the process to 1. acquire frozen cultures from the laboratories which generate the models, 2. authenticate, produce, preserve, develop, evaluate quality for quality assurance and 3. distribute globally the models and information to support high quality research in the life sciences. The distributor should be ready to work with models from up to 12 organ sites. It is expected that in the future, the distributor would provide this activity for the benefit of the research community.