ShEEP Request for Vevo 3100 Imaging System

ShEEP 请求 Vevo 3100 成像系统

• 批准号: 9213727
• 负责人: DAVID M ROTH
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9213727
• 关键词: Address; Age-Years; Animals; Blood flow; Cardiovascular system; Data Quality; Disease; Equipment; Female; Frequencies; Gene Delivery; Goals; Health; Heart Diseases; Image; Injection of therapeutic agent; Intervention; Investigation; Kidney; Left; Link; Measures; Morphologic artifacts; Mus; Myocardial; Myocardial Ischemia; Nephrology; Organ; Oryctolagus cuniculus; Pelvis; Phase; Population; Post-Traumatic Stress Disorders; Rattus; Renal Tissue; Reporting; Research; Research Personnel; Resolution; Services; Staging; Structure; System; Techniques; Technology; Time; Tissues; Ultrasonography; Ventricular; Veterans; Virus; Visual; agent orange; burden of illness; clinical investigation; cost efficient; data acquisition; high throughput analysis; image processing; imaging modality; imaging system; improved; male; non-invasive imaging; novel; pre-clinical; response; statistics; vector

Medical ultrasound techniques are widely used for pre-clinical investigations. These non-invasive imaging modalities are crucial for researchers to observe changes in organ/tissue structure, size, and blood flow during disease stages as well as in response to pharmacological interventions. The requested equipment is an ultra high-frequency ultrasound machine (Vevo3100, FUJIFILM, VisualSonics) specifically manufactured to image mice, rats, and rabbits. The Vevo 3100 system will be equipped with a linear phased array ultrasound probe specific for animals in the size range of rabbits that is not currently available on our existing equipment. The Vevo 3100 system also has several upgrades in the ultrasound technology including; 1) improved resolution, 2) reduced artifact, 3) real time image processing, 4) left ventricular tracing, 5) improved workflow for rapid data acquisition, 6) speckle tracking analysis (for strain analysis), 7) an imaging station equipped with injection mount (for echo guided tissue injections), and 8) a high throughput analysis. All these functionalities would make this system a necessary part of our goal to produce high quality data in a time and cost efficient manner. Additionally, the Vevo 3100 system with high- resolution ultrasound has applications in nephrology by providing excellent delineation of renal tissues, the technology to quantify and analyze kidney size, and the ability to measure blood flow throughout the pelvic region. The functionality of this novel Vevo 3100 will allow our cardiovascular research groups (Drs. Roth, Patel, Dillmann, Hammond, Ross, and Mahata) as well as our colleagues in the nephrology department (Drs. Sharma, Singh, and Rajasekaran) the opportunities to expand their experimental capabilities.

医学超声技术广泛用于临床前研究。这些非侵入性 成像方式对于研究人员观察器官/组织结构、大小和 血流在疾病阶段以及响应于药物干预。 所要求的设备是超高频超声机（Vevo 3100，FUJIFILM， VisualSonics），专门用于对小鼠、大鼠和家兔进行成像。 Vevo 3100系统将配备一个线性相控阵超声探头， 动物的大小范围内的兔子，目前还没有在我们现有的设备。的 Vevo 3100系统在超声技术方面也有几项升级，包括：1）改进 分辨率，2）伪影减少，3）真实的时间图像处理，4）左心室描记，5）改善 用于快速数据采集的工作流程，6）斑点跟踪分析（用于应变分析），7）成像 配备有注射座（用于回波引导组织注射）站，以及8）高通量 分析.所有这些功能将使该系统成为我们生产目标的必要组成部分 以时间和成本有效的方式提供高质量的数据。此外，Vevo 3100系统具有高- 分辨率超声通过提供良好的肾脏轮廓而在肾脏病学中具有应用 组织，量化和分析肾脏大小的技术，以及测量血流量的能力 在整个骨盆区域。 这种新型Vevo 3100的功能将使我们的心血管研究小组（罗斯博士， Patel、Dillmann、哈蒙德、Ross和Mahata）以及我们在肾脏病学的同事 部门（Sharma，Singh和Rajasekaran博士）有机会扩大他们的实验 能力的