Intervention and Implementation Science Core

项目摘要 艾滋病预防科学正处于一个显著的发展时期，这是由生物医学的引入所推动的。 预防模式，以补充传统的行为战略。新战略创造了 艾滋病毒预防和治疗成果之间的协同增效作用，其基础是认识到， 一套工具，如果正确组合使用，可以阻止流行病的传播，并有效治疗 绝大多数艾滋病毒感染者。最近的政策举措重点关注缩小差距 在预防和护理方面，以及在将干预措施转化为有效实践方面。我们建议增加 新的干预和实施科学（I&I）核心，推动艾滋病毒预防的科学发展 通过整合艾滋病干预科学领域的研究，包括基础研究、疗效研究、 试验和实施研究。I&I Core将遵循以下目标：（1）激励 跨学科的艾滋病毒干预科学的频谱的进展，通过利用最新的 在基础和艾滋病毒相关的生物医学，社会/行为，心理健康，公共卫生和技术方面的发现- 相关学科，为艾滋病毒干预设计，测试和扩大规模的创新提供信息; 确定临床、社会和行为干预之间的互补性和协同作用领域 支持加强联合和生物行为艾滋病毒预防方法的战略; 多学科科学家之间的合作，进行创新的干预研究，并指导 将有效的干预措施转化为实践。(2)磨练CAPS及其附属机构的技能 科学家们沿着艾滋病毒干预和实施科学的范围工作， 增加关于常规和尖端干预措施的制定和实施的知识 文化上可行的方法，可用于解决无数的预防目标，从 行为，结构和社会变革，以采用和坚持生物医学进步; 发展流利的学习和工作在不同的组织，政治和社会结构，以促进 将有效的干预措施转化为实践。(3)为了确保CAPS研究，包括干预和 实施研究，符合最高的道德标准，通过提供道德咨询来实现 研究项目中出现的问题;提高对伦理和人类问题的认识 在这个更多使用技术的时代，主题问题;并为数据的形成提供帮助， 安全监测委员会。

PROJECT SUMMARY HIV prevention science is in a period of marked evolution, prompted by the introduction of biomedical prevention modalities to complement traditional behavioral strategies. The new strategies have created synergies between HIV prevention and treatment outcomes, based on the recognition that there now exists a set of tools that, if utilized in the right combination, could stop the spread of the epidemic and effectively treat the vast majority of individuals living with HIV. Recent policy initiatives place a critical focus on closing the gaps in prevention and care, and on translating interventions into effective practice. We are proposing the addition of the new Intervention and Implementation Science (I&I) Core, to drive the scientific evolution in HIV prevention by integrating research across the spectrum of HIV intervention science, including basic research, efficacy trials, and implementation research. The I&I Core will be guided by the following aims: (1) To galvanize interdisciplinary advances across the spectrum of HIV intervention science, achieved by leveraging the latest findings in basic and HIV-related biomedical, social/behavioral, mental health, public health, and technology- related academic disciplines to inform innovations in HIV intervention design, testing, and scale-up; by identifying areas of complementariness and synergy among clinical, social, and behavioral intervention strategies to support enhanced combination and bio-behavioral HIV prevention approaches; and by fostering collaboration among multidisciplinary scientists to conduct innovative intervention research and guide the translation of effective interventions into practice. (2) To hone the skills among CAPS and its affiliated scientists for working along the spectrum of HIV intervention and implementation science, achieved by increasing knowledge about conventional and cutting-edge intervention development and implementation approaches that are culturally competent, and can be used to address myriad prevention targets, from behavioral, structural, and social change to adoption of and adherence to biomedical advances; and by developing fluency to study and work within diverse organizational, political, and social structures to foster the translation of effective interventions into practice. (3) To assure that CAPS research, including intervention and implementation research, meets the highest ethical standards, achieved by providing consultations on ethical and human subjects issues arising in research projects; increasing awareness about ethical and human subjects issues in this era of greater use of technology; and providing assistance in the formation of Data and Safety Monitoring Boards.