Neuroimaging Analysis Center (NAC)

神经影像分析中心（NAC）是生物医学技术资源中心（BTRC）计划的国家资源中心，该计划正在开发图像分析算法和软件工具，以提高对脑部疾病的理解并实现创新治疗。此竞争性续约申请侧重于医学成像数据的特定受试者分析。NAC的方法是一套技术专业知识和方法-图像分析，应用统计，张量处理，时间序列分析和软件工程-这将使该中心能够利用在以前的资金周期开发的基于地图集的技术，以改善对个体患者数据的分析。拟议的工作将在四个技术研究和开发（TRD）项目和一个基础设施项目中进行;它将通过外联和业务活动加以利用，其中包括使用3D Slicer的培训，该软件平台由中心支持。四个TRD包括微观结构成像、时空疾病建模、解剖变异性建模和切片机工程。NAC的研究人员团队由GE，UMass Worcester和波士顿大学的分包商组成，每个分包商都将为方法和基础设施开发提供独特的专业知识。驱动生物医学项目（DBPs）将确保所有中心活动继续与NIH受赠者高度相关。这些DBP包括慢性创伤性脑病，甲基苯丙胺成瘾和艾滋病，精神分裂症，阿尔茨海默病，亨廷顿病，自闭症和图像引导治疗的研究。将技术研究转化为3D Slicer作为外展平台是NAC作为资源中心的关键交付成果。作为外展活动的一部分，该中心将继续在地方和国家场馆提供支持和培训。与临床医生和科学家的密切合作仍然是至关重要的图像分析工具的实施，以了解大脑和治疗其疾病的目的，一个重要的使命的NIH。

The Neuroimage Analysis Center (NAC) is a National Resource Center in the Biomedical Technology Resource Center (BTRC) program that is developing image analysis algorithms and software tools to improve understanding of brain diseases and to enable innovative treatments. This competitive renewal application focuses on subject-specific analyses of medical imaging data. Underlying NAC's approach is a set of technical expertise and methodologies - Image analysis, applied statistics, tensor processing, time series analysis, and software engineering - that will enable the Center to exploit the atlas-based technologies developed in previous funding cycles to improve the analysis of individual patient data. The proposed work will be performed in four Technical Research and Development (TRD) projects and one Infrastructure project; it will be leveraged by outreach and operations activities, which include training in the use of 3D Slicer, the software platform supported by the Center. The four TRDs encompass microstructure imaging, spatio-temporal disease modeling, anatomical variability modeling, and Slicer engineering. The NAC team of investigators is augmented by subcontractors at GE, UMass Worcester, and Boston University, each of whom will provide unique expertise toward methodological and infrastructure development. The Driving Biomedical Projects (DBPs) will ensure that all Center activities continue to be highly relevant to NIH grantees. These DBPs include research in chronic traumatic encephalopathy, methamphetamine addiction and AIDS, schizophrenia, Alzheimer's disease, Huntington disease, autism, and image guided therapy. The translation of technological research into 3D Slicer as a platform for outreach represents a key deliverable In NAC's role as a resource center. The Center will continue to offer support and training at local and national venues as part of its outreach activities. Close collaboration with clinicians and scientists continues to be critical to the implementation of image analysis tools for the purpose of understanding the brain and treating Its disorders, an Important mission of the NIH.