Pathways involved in the insulin-like growth factor (IGF)-independent actions of IGF binding protein-6

参与 IGF 结合蛋白 6 的胰岛素样生长因子 (IGF) 独立作用的途径

• 批准号: nhmrc : 546016
• 负责人: Dr Ping Fu
• 金额: $ 36.72万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathways-involved-insulin-protein-6/95526
• 关键词: Pathways; involved; insulin; like; growth

Insulin-like growth factors (IGFs) are important proteins that regulate growth. When not regulated properly, diseases such as cancer can occur. A family of IGF binding proteins regulates IGFs. IGFBPs may inhibit IGFs and we have shown that one of them, IGFBP-6, decreases growth of some experimental cancers. As well as regulating IGFs, some IGFBPs alter cell behaviour independently of IGFs, and we found that IGFBP-6 stimulates cell movement in this way. We will now determine how this happens.

胰岛素样生长因子（IGFs）是调节生长的重要蛋白质。如果没有适当的监管，可能会发生癌症等疾病。IGF结合蛋白家族调节IGF。IGFBPs可以抑制IGFs，我们已经证明其中之一IGFBP-6可以减少一些实验性癌症的生长。除了调节IGFs外，一些IGFBP还独立于IGFs改变细胞行为，我们发现IGFBP-6以这种方式刺激细胞运动。我们现在将确定这是如何发生的。