Pathways that regulate nuclear export of circular RNA

环状RNA （circRNAs）是一类新兴且不寻常的RNA分子，在癌症的发生和发展中广泛存在并发挥重要作用。然而，负责circrna核输出的途径尚不清楚。我们在此建议系统地确定circRNA如何从细胞核输出，并描述调节circRNA输出通路在癌症中的作用。这将使我们能够确定circRNAs是否可以作为患者反应的生物标志物。

An emerging and unusual class of RNA molecules, circular RNAs (circRNAs), is widespread and plays important roles in cancer initiation and progression. However, the pathways responsible for nuclear export of circRNAs are unknown. We propose here to systematically determine how circRNAs are exported from the nucleus and characterise the effect of modulating circRNA export pathways in cancer. This will enable us to determine whether circRNAs can function as a biomarker of patient response.