Pathways that regulate nuclear export of circular RNA

一种新兴的和不寻常的RNA分子，环状RNA（circRNA），是广泛存在的，并在癌症的发生和发展中发挥重要作用。然而，负责circRNA的核输出的途径是未知的。我们在这里建议系统地确定circRNA是如何从细胞核中输出的，并研究调节circRNA输出途径在癌症中的作用。这将使我们能够确定circRNA是否可以作为患者反应的生物标志物。

An emerging and unusual class of RNA molecules, circular RNAs (circRNAs), is widespread and plays important roles in cancer initiation and progression. However, the pathways responsible for nuclear export of circRNAs are unknown. We propose here to systematically determine how circRNAs are exported from the nucleus and characterise the effect of modulating circRNA export pathways in cancer. This will enable us to determine whether circRNAs can function as a biomarker of patient response.