Perforin trafficking and activation in killer lymphocytes

穿孔素(PRF)是人体免疫应答过程中细胞毒性淋巴细胞功能所必需的蛋白质。缺乏PRF的人会受到严重的免疫抑制，如果他们感染了病毒，他们就会患上重病。PRF功能的部分丧失也会使个体更容易患上癌症。我们的目标是研究PRF的功能和生化特性。这项研究的结果将确定PRF如何影响人类的免疫系统和免疫动态平衡。

Perforin (PRF) is a protein essential for the function of cytotoxic lymphocytes during an immune response in humans. Humans deficient in PRF are severely immunosuppressed and fall critically ill if they contract a viral infection. The partial loss of PRF function can also predispose an individual to cancer. We aim to investigate the functional and biochemical properties of PRF. The outcomes of this study will determine how PRF influences the immune system and immune homeostasis in humans.