Pharmaceutical opioids for chronic non-cancer pain: Evaluating health outcomes and economic impact over five years

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Chronic non-cancer pain (CNCP) is a major contributor to disability. Increased opioid prescribing for CNCP has produced concern about dependence and overdose in the absence on data on its long-term effectiveness. Novel statistical methods will test causal relationships over 5 years between treatment, outcomes, and costs on 1,514 CNCP patients prescribed opioids. We will answer critical questions on 5-year outcomes, and whether, and for whom, opioids and other clinical interventions reduce costs.